4'-(3-Phenylpropoxy)acetophenone

Base Information

• Chemical Name: 4'-(3-Phenylpropoxy)acetophenone
• CAS No.: 54916-29-9
• Molecular Formula: C17H18O2
• Molecular Weight: 254.329
• DSSTox Substance ID: DTXSID301285169
• Wikidata: Q107862285
• Mol file: 54916-29-9.mol

Synonyms:4'-(3-Phenylpropoxy)acetophenone;SCHEMBL6952535;p-(3-phenylpropoxy) acetophenone;RYWVBYIATDKGDH-UHFFFAOYSA-N;DTXSID301285169;AKOS000203226;54916-29-9;1-[4-(3-PHENYLPROPOXY)PHENYL]ETHANONE

Chemical Property of 4'-(3-Phenylpropoxy)acetophenone

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 254.130679813
• Heavy Atom Count: 19
• Complexity: 260

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)OCCCC2=CC=CC=C2

Technology Process of 4'-(3-Phenylpropoxy)acetophenone

There total 2 articles about 4'-(3-Phenylpropoxy)acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Hydroxyacetophenone (99-93-4) → 4'-(3-phenylpropoxy)acetophenone (54916-29-9)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃;

DOI:10.1248/cpb.c19-00949

Reference yield:

→ 4'-(3-phenylpropoxy)acetophenone (54916-29-9)

Guidance literature:

4-Cinnamyloxy-acetophenon (F: 105-106grad), H2, Pd/Kohle, A., Saeure bzw. Base; neben anderen Verbb.;

Reference yield: 87.0%

4'-(3-phenylpropoxy)acetophenone (54916-29-9) + Methyltriphenylphosphonium bromide (1779-49-3) → 1-(3-phenylpropoxy)-4-(prop-1-en-2-yl)benzene

Guidance literature:

Methyltriphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h;

4'-(3-phenylpropoxy)acetophenone; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

DOI:10.1016/j.cclet.2021.10.083

upstream raw materials:

4-Hydroxyacetophenone

Downstream raw materials:

(E)-3-[4-(3-Phenyl-propoxy)-phenyl]-but-2-enoic acid methyl ester

(E)-3-[4-(3-Phenyl-propoxy)-phenyl]-but-2-enoic acid diethylamide