Technology Process of Fecosterol
There total 13 articles about Fecosterol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 88 percent / DMSO, oxalyl chloride / CH2Cl2 / 0.08 h / -78 °C
2: 1.) potassium tert-amylate / 1.) toluene, tert-amyl alcohol, 70 deg C, 40 min, 2.) 70 deg C, 40 min
With
oxalyl dichloride; potassium 2-methylbutan-2-olate; dimethyl sulfoxide;
In
dichloromethane;
DOI:10.1021/ja00183a042
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature
2: 88 percent / DMSO, oxalyl chloride / CH2Cl2 / 0.08 h / -78 °C
3: 1.) potassium tert-amylate / 1.) toluene, tert-amyl alcohol, 70 deg C, 40 min, 2.) 70 deg C, 40 min
With
oxalyl dichloride; tetrabutyl ammonium fluoride; potassium 2-methylbutan-2-olate; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00183a042
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridine, 4-(N,N-dimethylamino)pyridine / 12 h / 25 °C
2: 92 percent / Bu3SnH, AIBN / toluene / 0.33 h / 90 °C
3: 99 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature
4: 88 percent / DMSO, oxalyl chloride / CH2Cl2 / 0.08 h / -78 °C
5: 1.) potassium tert-amylate / 1.) toluene, tert-amyl alcohol, 70 deg C, 40 min, 2.) 70 deg C, 40 min
With
pyridine; dmap; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; potassium 2-methylbutan-2-olate; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja00183a042
