4-Hydroxy-4-(3-indolylmethyl)-2-ketoglutaric acid

Base Information

Chemical Name:4-Hydroxy-4-(3-indolylmethyl)-2-ketoglutaric acid
CAS No.:551958-84-0
Molecular Formula:C14H13NO6
Molecular Weight:291.26
Hs Code.:
DSSTox Substance ID:DTXSID30436171

Synonyms:4-hydroxy-4-(3-indolylmethyl)-2-ketoglutaric acid;551958-84-0;SCHEMBL125605;SCHEMBL13844617;DTXSID30436171;SLWQCDYJBNGHQV-UHFFFAOYSA-N;4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid

Suppliers and Price of 4-Hydroxy-4-(3-indolylmethyl)-2-ketoglutaric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4-Hydroxy-4-(3-indolylmethyl)-2-ketoglutaric acid

Chemical Property:

XLogP3:0.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:291.07428713
Heavy Atom Count:21
Complexity:451

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=CN2)CC(CC(=O)C(=O)O)(C(=O)O)O

Technology Process of 4-Hydroxy-4-(3-indolylmethyl)-2-ketoglutaric acid

There total 1 articles about 4-Hydroxy-4-(3-indolylmethyl)-2-ketoglutaric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57-60-3
piruvate

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

: 551958-84-0
4-hydroxy-4-(3-indolylmethyl)-2-ketoglutaric acid

: 146142-94-1
(2S,4S)-2-((1H-indol-3-yl)methyl)-4-amino-2-hydroxypentane-1,5-dioic acid

Guidance literature:: piruvate; L-Tryptophan; With magnesium chloride; pyridoxal 5'-phosphate; at 30 ℃; pH=7.5 - 7.8; Inert atmosphere; phosphate buffer; Enzymatic reaction;

With L-alanin; at 30 ℃; pH=7.5 - 7.8; Product distribution / selectivity; Inert atmosphere; Enzymatic reaction;

Reference yield:

: 551958-84-0
4-hydroxy-4-(3-indolylmethyl)-2-ketoglutaric acid

: 146142-94-1
(2S,4S)-2-((1H-indol-3-yl)methyl)-4-amino-2-hydroxypentane-1,5-dioic acid

Guidance literature:: With pyridoxal 5'-phosphate; tris hydrochloride; monosodium glutamate; Aeromonas hydrophila IFO₃₈₂₀; In water; toluene; at 30 ℃; for 16h; pH=7.6; Product distribution / selectivity; Enzymatic reaction; Culture medium;

Reference yield:

: 551958-84-0
4-hydroxy-4-(3-indolylmethyl)-2-ketoglutaric acid

: C₂₂H₂₀N₂O₆

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; hydroxylamine hydrochloride / water / 17.5 h / 5 °C / pH 7

2: rhodium contaminated with carbon; hydrogen; ammonium hydroxide / 24 h / 20 °C / 7500.75 Torr

3: sodium hydroxide / water / 20 °C

4: toluene-4-sulfonic acid / ethyl acetate / 2 h / 75 °C

With ammonium hydroxide; rhodium contaminated with carbon; hydroxylamine hydrochloride; hydrogen; toluene-4-sulfonic acid; sodium hydroxide; In water; ethyl acetate;
DOI:10.1248/cpb.c16-00286