1,3-DIOXOLO(4,5-g)QUINAZOLIN-6(5H)-ONE, 8-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-

Base Information

Chemical Name:1,3-DIOXOLO(4,5-g)QUINAZOLIN-6(5H)-ONE, 8-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-
CAS No.:33100-30-0
Molecular Formula:C18H15FN2O3
Molecular Weight:326.3217
Hs Code.:
UNII:65TP3SJ5YA
DSSTox Substance ID:DTXSID40186771
Wikidata:Q27263914
ChEMBL ID:CHEMBL13525

Synonyms:BRN 0571260;UNII-65TP3SJ5YA;65TP3SJ5YA;1,3-DIOXOLO(4,5-g)QUINAZOLIN-6(5H)-ONE, 8-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-;1-Isopropyl-4-(p-fluorophenyl)-6,7-methylenedioxy-2(1H)-quinazolinone;33100-30-0;8-(4-Fluorophenyl)-5-isopropyl-1,3-dioxolo(4,5-g)quinazolin-6(5H)-one;CHEMBL13525;SCHEMBL11087025;DTXSID40186771;SaH-46-798;LS-62833;PD159581;Q27263914;1,3-DIOXOLO(4,5-G)QUINAZOLIN-6(5H)-ONE, 8-(P-FLUOROPHENYL)-5-ISOPROPYL-

Suppliers and Price of 1,3-DIOXOLO(4,5-g)QUINAZOLIN-6(5H)-ONE, 8-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,3-DIOXOLO(4,5-g)QUINAZOLIN-6(5H)-ONE, 8-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-

Chemical Property:

Vapor Pressure:1.97E-09mmHg at 25°C
Boiling Point:481.6°Cat760mmHg
Flash Point:245°C
Density:1.38g/cm³
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:326.10667051
Heavy Atom Count:24
Complexity:530

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)N1C2=CC3=C(C=C2C(=NC1=O)C4=CC=C(C=C4)F)OCO3

Technology Process of 1,3-DIOXOLO(4,5-g)QUINAZOLIN-6(5H)-ONE, 8-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-

There total 5 articles about 1,3-DIOXOLO(4,5-g)QUINAZOLIN-6(5H)-ONE, 8-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 33095-80-6
1-isopropyl-4-(p-fluorophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone

: 33100-30-0
1-isopropyl-6,7-methylenedioxy-4-(p-fluorophenyl)quinazolin-2(1H)-one

Guidance literature:: With potassium permanganate; In 1,4-dioxane; water;
DOI:10.1021/jm00351a022

Reference yield:

: 10368-14-6
N-isopropyl-3,4-(methylenedioxy)aniline

: 33100-30-0
1-isopropyl-6,7-methylenedioxy-4-(p-fluorophenyl)quinazolin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / HOAc / 15 h / Ambient temperature

2: 50 percent / CH₃SO₃H / toluene / 21 h / Heating

3: 81 percent / KMnO₄ / dioxane; H₂O

With potassium permanganate; methanesulfonic acid; acetic acid; In 1,4-dioxane; water; toluene;
DOI:10.1021/jm00351a022

Reference yield:

: 33095-94-2
N-isopropyl-N-[3,4-(methylenedioxy)phenyl]urea

: 33100-30-0
1-isopropyl-6,7-methylenedioxy-4-(p-fluorophenyl)quinazolin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / CH₃SO₃H / toluene / 21 h / Heating

2: 81 percent / KMnO₄ / dioxane; H₂O

With potassium permanganate; methanesulfonic acid; In 1,4-dioxane; water; toluene;
DOI:10.1021/jm00351a022