Cyclooctanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]-4, 4-dimethyl-8-methylene-7-[1-methylene-4-[(triethylsilyl)oxy]butyl]-2,6-bis( phenylmethoxy)-, (2R,3R,5R,6S,7R)-

Base Information

Chemical Name:Cyclooctanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]-4, 4-dimethyl-8-methylene-7-[1-methylene-4-[(triethylsilyl)oxy]butyl]-2,6-bis( phenylmethoxy)-, (2R,3R,5R,6S,7R)-
CAS No.:553628-47-0
Molecular Formula:C50H74O7Si2
Molecular Weight:843.304
Hs Code.:

Cyclooctanone,
3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]-4,
4-dimethyl-8-methylene-7-[1-methylene-4-[(triethylsilyl)oxy]butyl]-2,6-bis(
phenylmethoxy)-, (2R,3R,5R,6S,7R)-

Synonyms:

Suppliers and Price of Cyclooctanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]-4, 4-dimethyl-8-methylene-7-[1-methylene-4-[(triethylsilyl)oxy]butyl]-2,6-bis( phenylmethoxy)-, (2R,3R,5R,6S,7R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclooctanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]-4, 4-dimethyl-8-methylene-7-[1-methylene-4-[(triethylsilyl)oxy]butyl]-2,6-bis( phenylmethoxy)-, (2R,3R,5R,6S,7R)-

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Technology Process of Cyclooctanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]-4, 4-dimethyl-8-methylene-7-[1-methylene-4-[(triethylsilyl)oxy]butyl]-2,6-bis( phenylmethoxy)-, (2R,3R,5R,6S,7R)-

There total 6 articles about Cyclooctanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[(4-methoxyphenyl)methoxy]-4, 4-dimethyl-8-methylene-7-[1-methylene-4-[(triethylsilyl)oxy]butyl]-2,6-bis( phenylmethoxy)-, (2R,3R,5R,6S,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 677751-20-1
(1R,3R,4R,6R,7S,8R)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-6-(methoxybenzyloxy)-5,5-dimethyl-8-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctylmethyl acetate

: 553628-47-0
(2R,3R,5R,6S,7R)-2,6-bis(benzyloxy)-3-(t-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-4,4-dimethyl-8-methylene-7-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctanone

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1246/bcsj.78.677

Reference yield: 71.0%

: 178626-24-9
2-bromo-5-(triethylsilyloxy)pentene

: (4S,5R,7R,8R)-4,8-bis(benzyloxy)-7-(t-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-6,6-dimethylcyclooct-2-enone

: 553628-47-0
(2R,3R,5R,6S,7R)-2,6-bis(benzyloxy)-3-(t-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-4,4-dimethyl-8-methylene-7-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctanone

: 553628-46-9
(2R,3R,5R,6S,7S,8R)-2,6-bis(benzyloxy)-3-(t-butyldimethylsilyloxy)-8-hydroxymethyl-5-(4-methoxybenzyloxy)-4,4-dimethyl-7-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctanone

Guidance literature:: (4S,5R,7R,8R)-4,8-bis(benzyloxy)-7-(t-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-6,6-dimethylcyclooct-2-enone; With trimethylaluminum; In diethyl ether; hexane; at 0 ℃; for 0.5h;

2-bromo-5-(triethylsilyloxy)pentene; With tert.-butyl lithium; In diethyl ether; hexane; pentane; at -23 ℃; for 1h;

With ammonium chloride; In diethyl ether; hexane; pentane; at -78 ℃;

Reference yield:

: 553628-46-9
(2R,3R,5R,6S,7S,8R)-2,6-bis(benzyloxy)-3-(t-butyldimethylsilyloxy)-8-hydroxymethyl-5-(4-methoxybenzyloxy)-4,4-dimethyl-7-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctanone

: 553628-47-0
(2R,3R,5R,6S,7R)-2,6-bis(benzyloxy)-3-(t-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-4,4-dimethyl-8-methylene-7-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctanone

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / DMAP; pyridine / 1 h / 0 °C

2: 85 percent / DBU / CH₂Cl₂ / 1.5 h / 20 °C

With pyridine; dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane;
DOI:10.1246/bcsj.78.677