(1R,3R,4R,6R,7S,8R)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-6-(methoxybenzyloxy)-5,5-dimethyl-8-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctylmethyl acetate

Base Information

Chemical Name:(1R,3R,4R,6R,7S,8R)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-6-(methoxybenzyloxy)-5,5-dimethyl-8-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctylmethyl acetate
CAS No.:677751-20-1
Molecular Formula:C₅₂H₇₈O₉Si₂
Molecular Weight:903.357
Hs Code.:

(1R,3R,4R,6R,7S,8R)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-6-(methoxybenzyloxy)-5,5-dimethyl-8-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctylmethyl acetate

Synonyms:(1R,3R,4R,6R,7S,8R)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-6-(methoxybenzyloxy)-5,5-dimethyl-8-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctylmethyl acetate

Suppliers and Price of (1R,3R,4R,6R,7S,8R)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-6-(methoxybenzyloxy)-5,5-dimethyl-8-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctylmethyl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,3R,4R,6R,7S,8R)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-6-(methoxybenzyloxy)-5,5-dimethyl-8-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctylmethyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,3R,4R,6R,7S,8R)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-6-(methoxybenzyloxy)-5,5-dimethyl-8-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctylmethyl acetate

There total 4 articles about (1R,3R,4R,6R,7S,8R)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-6-(methoxybenzyloxy)-5,5-dimethyl-8-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctylmethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 108-24-7
acetic anhydride

: 553628-46-9
(2R,3R,5R,6S,7S,8R)-2,6-bis(benzyloxy)-3-(t-butyldimethylsilyloxy)-8-hydroxymethyl-5-(4-methoxybenzyloxy)-4,4-dimethyl-7-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctanone

: 677751-20-1
(1R,3R,4R,6R,7S,8R)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-6-(methoxybenzyloxy)-5,5-dimethyl-8-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctylmethyl acetate

Guidance literature:: With dmap; In pyridine;
DOI:10.1246/cl.2004.124

Reference yield:

: (2S,3R,5R,6R)-2,6-bis(benzyloxy)-3-(t-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-4,4-dimethyl-7-oxo-8-(triethylsilyloxymethyl)cyclooctyl acetate

: 677751-20-1
(1R,3R,4R,6R,7S,8R)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-6-(methoxybenzyloxy)-5,5-dimethyl-8-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctylmethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 26 percent / DBU / benzene / 0.5 h / 20 °C

2.1: t-butyllithium / diethyl ether / 0.5 h / -78 °C

2.2: CuCN / diethyl ether / 0.33 h / -23 °C

2.3: 71 percent / trimethylaluminium / diethyl ether; hexane / 1 h / -23 °C

3.1: 89 percent / DMAP; pyridine / 1 h / 0 °C

With pyridine; dmap; tert.-butyl lithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; benzene;
DOI:10.1246/bcsj.78.677

Reference yield:

: 178626-24-9
2-bromo-5-(triethylsilyloxy)pentene

: 677751-20-1
(1R,3R,4R,6R,7S,8R)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-6-(methoxybenzyloxy)-5,5-dimethyl-8-[1-methylene-4-(triethylsilyloxy)butyl]cyclooctylmethyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-butyllithium / diethyl ether / 0.5 h / -78 °C

1.2: CuCN / diethyl ether / 0.33 h / -23 °C

1.3: 71 percent / trimethylaluminium / diethyl ether; hexane / 1 h / -23 °C

2.1: 89 percent / DMAP; pyridine / 1 h / 0 °C

With pyridine; dmap; tert.-butyl lithium; In diethyl ether;
DOI:10.1246/bcsj.78.677