4-methyl-N-(2-methylphenyl)benzamide

Base Information

• Chemical Name: 4-methyl-N-(2-methylphenyl)benzamide
• CAS No.: 55577-26-9
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• DSSTox Substance ID: DTXSID201290098
• Nikkaji Number: J1.989.552A
• Mol file: 55577-26-9.mol

Synonyms:4-methyl-N-(2-methylphenyl)benzamide;55577-26-9;4-Methyl-N-(o-tolyl)benzamide;AURORA 918;N-(2-Methylphenyl)-4-methylbenzamide;starbld0011514;Cambridge id 5360880;SCHEMBL3690383;DTXSID201290098;HMS1609E12;MFCD00704225;AKOS001610241;CS-0281244;AB00082966-01;SR-01000416260;SR-01000416260-1;Z27793254

Chemical Property of 4-methyl-N-(2-methylphenyl)benzamide

Chemical Property:

• PSA: 29.10000
• LogP: 3.62870
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 225.115364102
• Heavy Atom Count: 17
• Complexity: 256

Purity/Quality:

99% ^*data from raw suppliers

BENZAMIDE,4-METHYL-N-(2-METHYLPHENYL)- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2C

Technology Process of 4-methyl-N-(2-methylphenyl)benzamide

There total 6 articles about 4-methyl-N-(2-methylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

carbon monoxide (201230-82-2) + 4-methylphenylboronic acid (5720-05-8) + 2-methylphenyl diazonium tetrafluoroborate (2093-46-1) → N-(2-methylphenyl)-4-methyl-benzamide (55577-26-9)

Guidance literature:

With ammonia; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; palladium diacetate; In tetrahydrofuran; at 20 ℃; for 3h; under 3800 Torr;

DOI:10.1055/s-2003-42478

Reference yield: 76.0%

4-methyl-benzoyl chloride (874-60-2) + o-toluidine (95-53-4) → N-(2-methylphenyl)-4-methyl-benzamide (55577-26-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 25 ℃; for 12h; Cooling with ice;

DOI:10.1021/jm3013097

Reference yield:

1-azido-2-methyl-benzene (31656-92-5) + C8H7OSe(1-)*Li(1+) → N-(2-methylphenyl)-4-methyl-benzamide (55577-26-9)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tet.2020.131834

upstream raw materials:

4-methyl-benzoyl chloride

o-toluidine

carbon monoxide

4-methylphenylboronic acid

Downstream raw materials:

2-(4-methylphenyl)-4H-3,1-benzoxazine

C₂₄H₂₃NO₃S

[2-(4-methylphenyl)indol-3-yl]glyoxylyl chloride

2-(4-methylphenyl)-1H-indole