4-(3-methoxyphenyl)butanoic acid

Base Information

• Chemical Name: 4-(3-methoxyphenyl)butanoic acid
• CAS No.: 24743-11-1
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Mol file: 24743-11-1.mol

Synonyms:m-Methoxyphenylbutyric acid;

Chemical Property of 4-(3-methoxyphenyl)butanoic acid

Chemical Property:

• Vapor Pressure: 5.09E-05mmHg at 25°C
• Refractive Index: 1.525
• Boiling Point: 334.3°Cat760mmHg
• Flash Point: 129.1°C
• PSA: 46.53000
• Density: 1.116g/cm³
• LogP: 2.10250

Purity/Quality:

97% ^*data from raw suppliers

4-(3-METHOXY-PHENYL)-BUTYRIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-methoxyphenyl)butanoic acid

There total 33 articles about 4-(3-methoxyphenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(E)-4-(m-methoxyphenyl)but-3-enoic acid (137744-81-1) → 4-(m-methoxyphenyl)butanoic acid (24743-11-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 1h;

DOI:10.1021/jm400336x

Reference yield: 94.0%

but-3-enoic acid (625-38-7) + 3-methoxyphenylboronic acid (10365-98-7,1107579-37-2) → 4-(m-methoxyphenyl)butanoic acid (24743-11-1)

Guidance literature:

With propan-1-ol; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium tert-butylate; 4,4-dibenzyl-2-(pyridin-2-yl)-4,5-dihydrooxazole; at 60 ℃; Reagent/catalyst; regioselective reaction; Sealed tube;

DOI:10.1002/anie.202010840

Reference yield:

3-(3'-methoxyphenyl)-1-butyronitrile (91152-85-1) → 4-(m-methoxyphenyl)butanoic acid (24743-11-1)

Guidance literature:

With potassium hydroxide;

DOI:10.1039/jr9350001288

upstream raw materials:

4-(3-methoxy-phenyl)-4-oxo-butyric acid

(3-methoxy-phenethyl)-malonic acid diethyl ester

3-(3'-methoxyphenyl)-1-butyronitrile

ethyl 4-(3'-methoxyphenyl)butyrate

Downstream raw materials:

ethyl 4-(3'-methoxyphenyl)butyrate

6-methoxy-3,4-dihydro-1(2H)-naphthalenone

γ-(2-bromo-5-methoxyphenyl)butyric acid

8-methoxy-1-tetralone