8-Methoxy-3,4-dihydronaphthalen-1(2H)-one

Base Information

• Chemical Name: 8-Methoxy-3,4-dihydronaphthalen-1(2H)-one
• CAS No.: 13185-18-7
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Hs Code.: 2914509090
• Mol file: 13185-18-7.mol

Synonyms:8-Methoxy-1-tetralone;8-Methoxy-3,4-dihydronaphthalen-1(2H)-one;8-Methoxytetralone;8-Methoxy-α-Tetralone;

Chemical Property of 8-Methoxy-3,4-dihydronaphthalen-1(2H)-one

Chemical Property:

• Vapor Pressure: 0.000239mmHg at 25°C
• Melting Point: 128-130℃
• Refractive Index: 1.548
• Boiling Point: 324.8 °C at 760 mmHg
• Flash Point: 154.5 °C
• PSA: 26.30000
• Density: 1.124 g/cm³
• LogP: 2.21420
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Methoxy-3,4-Dihydronaphthalen-1(2h)-One ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Methoxy-3,4-dihydronaphthalen-1(2H)-one

There total 21 articles about 8-Methoxy-3,4-dihydronaphthalen-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-Brom-8-methoxy-1,2,3,4-tetrahydro-1-naphthalinon (77259-96-2) → 8-methoxy-1-tetralone (13185-18-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 24h;

DOI:10.1080/00304948.2010.514837

Reference yield: 92.0%

8-hydroxy-1,2,3,4-tetrahydro-1-naphthalenone (7695-47-8) + methyl iodide (74-88-4) → 8-methoxy-1-tetralone (13185-18-7)

Guidance literature:

8-hydroxy-1,2,3,4-tetrahydro-1-naphthalenone; With potassium carbonate; In acetone; for 0.5h; Inert atmosphere;

methyl iodide; In acetone; for 8h; Inert atmosphere; Reflux;

DOI:10.1039/c6ob02719a

Reference yield: 92.0%

8-hydroxy-1,2,3,4-tetrahydro-1-naphthalenone (7695-47-8) + dimethyl sulfate (77-78-1) → 8-methoxy-1-tetralone (13185-18-7)

Guidance literature:

With potassium carbonate; In acetone; for 30h; Heating;

DOI:10.1016/0223-5234(87)90275-3

upstream raw materials:

ethoxydimethylvinylsilane

N,N-diethyl-2-methoxy-6-methylbenzamide

5-Brom-8-methoxy-1,2,3,4-tetrahydro-1-naphthalinon

methyl 2-methyl-6-methoxybenzoate

Downstream raw materials:

N-[8-Bromo-5-methoxy-4a-methyl-4,4a,9,10-tetrahydro-3H-phenanthren-(2E)-ylidene]-N'-(2,4-dinitro-phenyl)-hydrazine

4,5-dihydro-3H-naphtho<1,8-bc>furan

8-hydroxymethyl-1,2,3,4-tetrahydro-1-naphthalenone

Refernces

• 1、 Rastelli, Giulio,Costantino, Luca,Vianello, Paola,Barlocco, Daniela. "Free energy perturbation studies on binding of the inhibitor 5,6- dihydrobenzo[h]cinnolin-3(2H)one-2-acetic acid and its methoxylated analogs to aldose reductase". . p. 9415 - 9428. Retrieved 1998.
• 2、 Chen, Lei,Su, Mei,Jin, Qiu,Wang, Wei,Wang, Chun-Gu,Assani, Israa,Wang, Mu-Xuan,Zhao, Shi-Feng,Lv, Shen-Min,Wang, Jia-Wei,Sun, Bo,Li, Yan,Liao, Zhi-Xin. "Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist". . p. 16106 - 16131. Retrieved 2021/11/18.
• 3、 Ning, Yingtang,Fukuda, Tomoya,Ikeda, Hirotaka,Otani, Yuko,Kawahata, Masatoshi,Yamaguchi, Kentaro,Ohwada, Tomohiko. "Revisiting secondary interactions in neighboring group participation, exemplified by reactivity changes of iminylium intermediates". supporting information. p. 1381 - 1392. Retrieved 2017/02/15.