Carbamic acid, [(1R)-1-formyl-2,2-dimethoxypropyl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [(1R)-1-formyl-2,2-dimethoxypropyl]-, phenylmethyl ester
CAS No.:560130-27-0
Molecular Formula:C14H19NO5
Molecular Weight:281.309
Hs Code.:

Synonyms:

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Chemical Property of Carbamic acid, [(1R)-1-formyl-2,2-dimethoxypropyl]-, phenylmethyl ester

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Technology Process of Carbamic acid, [(1R)-1-formyl-2,2-dimethoxypropyl]-, phenylmethyl ester

There total 5 articles about Carbamic acid, [(1R)-1-formyl-2,2-dimethoxypropyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 560130-31-6
(2R)-3-(benzyloxycarbonyl)amino-3,3-dimethoxybutanol

: 560130-27-0
(2R)-3-(benzyloxycarbonyl)amino-3,3-dimethoxybutanal

Guidance literature:: With dipyridinium dichromate; 4 A molecular sieve; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1016/S0040-4020(03)00378-8

Reference yield:

: 19728-63-3
N-benzyloxycarbonyl-L-treonine

: 560130-27-0
(2R)-3-(benzyloxycarbonyl)amino-3,3-dimethoxybutanal

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / borane methylsulfide complex / tetrahydrofuran / 16 h / 0 - 20 °C

2: 56 percent / Et₃N / CH₂Cl₂ / 12 h / 0 - 20 °C

3: 92 percent / sulfur trioxide pyridin complex; Et₃N / dimethylsulfoxide / 2.5 h / 20 °C

4: 97 percent / p-TsOH*H₂O / methanol / 2.5 h / 20 °C

5: 94 percent / TBAF / tetrahydrofuran / 1.5 h / 20 °C

6: 71 percent / PDC; molecular sieves 4 Angstroem / CH₂Cl₂ / 1.5 h / 20 °C

With dipyridinium dichromate; borane methylsulfide; 4 A molecular sieve; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(03)00378-8

Reference yield:

: 161150-55-6
(2R,3R)-2-(benzyloxycarbonyl)amino-1,3-butanediol

: 560130-27-0
(2R)-3-(benzyloxycarbonyl)amino-3,3-dimethoxybutanal

Guidance literature:: Multi-step reaction with 5 steps

1: 56 percent / Et₃N / CH₂Cl₂ / 12 h / 0 - 20 °C

2: 92 percent / sulfur trioxide pyridin complex; Et₃N / dimethylsulfoxide / 2.5 h / 20 °C

3: 97 percent / p-TsOH*H₂O / methanol / 2.5 h / 20 °C

4: 94 percent / TBAF / tetrahydrofuran / 1.5 h / 20 °C

5: 71 percent / PDC; molecular sieves 4 Angstroem / CH₂Cl₂ / 1.5 h / 20 °C

With dipyridinium dichromate; 4 A molecular sieve; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(03)00378-8