2',4'-Dihydroxy-4,6'-dimethoxychalcone

Base Information

• Chemical Name: 2',4'-Dihydroxy-4,6'-dimethoxychalcone
• CAS No.: 56121-44-9
• Molecular Formula: C17H16O5
• Molecular Weight: 300.311
• Mol file: 56121-44-9.mol

Synonyms:

Chemical Property of 2',4'-Dihydroxy-4,6'-dimethoxychalcone

Chemical Property:

• PSA: 75.99000
• LogP: 3.01110

Purity/Quality:

98%Min ^*data from raw suppliers

4-O-Methylhelichrysetin 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',4'-Dihydroxy-4,6'-dimethoxychalcone

There total 15 articles about 2',4'-Dihydroxy-4,6'-dimethoxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(E)-1-(2-hydroxy-6-methoxy-4-(methoxymethoxy)phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (404597-92-8) → (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one (56121-44-9)

Guidance literature:

With hydrogenchloride; In methanol; for 0.5h; Heating;

Reference yield: 84.0%

C31H28O5 → (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one (56121-44-9)

Guidance literature:

With boron trichloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.2174/1570180817999200531162015

Reference yield: 80.4%

(2E)-1-[2-methoxy-4,6-bis(2-propenyloxy)phenyl]-3-(4-methoxyphenyl)-2-propen-1-one (1070781-84-8) → (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one (56121-44-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; at 60 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm800812k

upstream raw materials:

2'-hydroxy-4'-benzyloxy-4,6'-dimethoxychalkone

4-methoxy-benzaldehyde

(E)-1-(2-hydroxy-6-methoxy-4-(methoxymethoxy)phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

2,4,6-trihydroxyacetophenone

Downstream raw materials:

7-hydroxy-5-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one

2',4'-diacetoxy-4,6'-dimethoxydihydrochalkone

2'-acetoxy-4,4',6'-trimethoxydihydrochalkone

2'-hydroxy-4,4',6'-trimethoxydihydrochalcone

Refernces

• 1、 Zhang, Baoxin,Duan, Dongzhu,Ge, Chunpo,Yao, Juan,Liu, Yaping,Li, Xinming,Fang, Jianguo. "Synthesis of xanthohumol analogues and discovery of potent thioredoxin reductase inhibitor as potential anticancer agent". . p. 1795 - 1805. Retrieved 2015/04/27.
• 2、 Aponte, Jose C.,Castillo, Denis,Estevez, Yannick,Gonzalez, German,Arevalo, Jorge,Hammond, Gerald B.,Sauvain, Michel. "In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones". scheme or table. p. 100 - 103. Retrieved 2010/04/06.