Butanedioic acid, 2-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]-3-[[3-(phenylmethoxy) phenyl]methyl]-, 4-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S)-

Base Information

Chemical Name:Butanedioic acid, 2-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]-3-[[3-(phenylmethoxy) phenyl]methyl]-, 4-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S)-
CAS No.:561302-65-6
Molecular Formula:C₃₉H₄₉NO₇
Molecular Weight:643.821
Hs Code.:

Butanedioic acid,
2-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]-3-[[3-(phenylmethoxy)
phenyl]methyl]-, 4-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S)-

Synonyms:

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Chemical Property of Butanedioic acid, 2-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]-3-[[3-(phenylmethoxy) phenyl]methyl]-, 4-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S)-

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Technology Process of Butanedioic acid, 2-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]-3-[[3-(phenylmethoxy) phenyl]methyl]-, 4-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S)-

There total 7 articles about Butanedioic acid, 2-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]-3-[[3-(phenylmethoxy) phenyl]methyl]-, 4-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 561302-65-6
2-(3-benzyloxy-benzyl)-3-(1-tert-butoxycarbonyl-piperidin-4-yl)-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaN(TMS)2 / tetrahydrofuran / -78 - -22 °C

2: H₂O₂; LiOH

3: LDA; HMPA / tetrahydrofuran / -78 - 20 °C

4: DBU / benzene

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; dihydrogen peroxide; sodium hexamethyldisilazane; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In tetrahydrofuran; benzene;
DOI:10.1016/S0960-894X(03)00124-0

Reference yield:

: 96995-06-1
1-(benzyloxy)-3-(iodomethyl)benzene

: 561302-65-6
2-(3-benzyloxy-benzyl)-3-(1-tert-butoxycarbonyl-piperidin-4-yl)-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: LDA; HMPA / tetrahydrofuran / -78 - 20 °C

2: DBU / benzene

With N,N,N,N,N,N-hexamethylphosphoric triamide; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In tetrahydrofuran; benzene;
DOI:10.1016/S0960-894X(03)00124-0

Reference yield:

: 157688-46-5
2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid

: 561302-65-6
2-(3-benzyloxy-benzyl)-3-(1-tert-butoxycarbonyl-piperidin-4-yl)-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: LiCl; Piv-Cl / tetrahydrofuran

2: NaN(TMS)2 / tetrahydrofuran / -78 - -22 °C

3: H₂O₂; LiOH

4: LDA; HMPA / tetrahydrofuran / -78 - 20 °C

5: DBU / benzene

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; dihydrogen peroxide; sodium hexamethyldisilazane; pivaloyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; benzene;
DOI:10.1016/S0960-894X(03)00124-0