157688-46-5

Basic information

• Product Name: 1-Boc-4-piperidylacetic acid
• Synonyms: N-TERT-BUTOXYCARBONYLPIPERIDINE-4-ACETIC ACID;N-TERT-BUTOXYCARBONYL-4-CARBOXYMETHYLPIPERIDINE;N-T-BUTOXYCARBONYLPIPERIDINE-4-ACETIC ACID;N-T-BUTOXYCARBONYL-4-PIPERIDYLACETIC ACID;N-T-BUTOXYCARBONYL-4-CARBOXYMETHYLPIPERIDINE;N-BOC-PIPERIDINYL-4-ACETIC ACID;N-BOC-4-PIPERIDINEACETIC ACID;RARECHEM EM WB 0085
• CAS NO: 157688-46-5
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.3
• Product Categories: blocks;Carboxes;pharmacetical;Carboxylic Acids;Pyrans, Piperidines &Piperazines;Piperidine;Organic acids;Carboxylic Acids;Pyrans, Piperidines & Piperazines
• Mol File: 157688-46-5.mol
• Article Data: 30

Chemical Properties

• Melting Point: 96-98°C
• Boiling Point: 373 °C at 760 mmHg
• Flash Point: 179.4 °C
• Appearance: Yellow to brown/Powder, Solid or Crystalline Powder
• Density: 1.121 g/cm³
• Vapor Pressure: 1.37E-06mmHg at 25°C
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 4.66±0.10(Predicted)
• BRN: 7028968
• CAS DataBase Reference: 1-Boc-4-piperidylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-piperidylacetic acid(157688-46-5)
• EPA Substance Registry System: 1-Boc-4-piperidylacetic acid(157688-46-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 157688-46-5(Hazardous Substances Data)

Usage

Chemical Properties

Solid

InChI:InChI=1/C12H21NO4/c1-12(2,3)17-11(16)13-6-4-9(5-7-13)8-10(14)15/h9H,4-8H2,1-3H3,(H,14,15)/p-1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 51052-78-9 4-piperidinylacetic acid 
• 135716-09-5 tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate 
• 498-94-2 isonipecotic acid 
• 55-22-1 pyridine-4-carboxylic acid 
• 773837-37-9 sodium cyanide 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 59184-90-6 ethyl (piperidin-4-yl)acetate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 41979-39-9 4-piperidone hydrochloride 
• 135716-08-4 tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 175213-46-4 1-t-Butoxycarbonyl-4-(methoxycarbonylmethyl)piperidine 
• 6622-91-9 2-(pyridine-4-yl)acetic acid hydrochloride 

Downstream Products

• 175213-46-4 1-t-Butoxycarbonyl-4-(methoxycarbonylmethyl)piperidine 
• 416852-69-2 tert-butyl 4-{2-[methoxy(methyl)amino]-2-oxoethyl}piperidine-1-carboxylate 
• 896127-55-2 tert-butyl-4-{2-[(3,4-difluorobenzyl)amino]-2-oxoethyl}piperidine-1-carboxylate 
• 896127-78-9 tert-butyl 4-(2-{[(5-chloro-6-methoxypyridin-3-yl)(4-fluorophenyl)methyl]amino}-2-oxoethyl)piperidine-1-carboxylate 
• 301232-40-6 4-((N-(4-(trifluoromethyl)benzyl)carbamoyl)methyl)-piperidine hydrochloride 
• 502482-53-3 C₂₇H₄₃N₃O₃ 
• 718637-45-7 N-(4-methylthiophenyl)-1-tert-butoxycarbonylpiperidin-4-ylacetamide 
• 1237526-42-9 C₂₄H₂₉ClN₂O₃ 
• 916791-39-4 4-(3-ethoxycarbonyl-2-oxopropyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1292321-47-1 C₂₉H₃₄F₂N₂O₅ 
• 1292321-48-2 C₂₂H₂₃F₂NO₄ 

Relevant articles and documents

GLP-1R AGONISTS AND USES THEREOF

Provided are compounds of Formula (I) and pharmaceutical compositions thereof, for use in, e.g. treating type 2 diabetes mellitus, pre-diabetes, obesity, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and cardiovascular disease.

High-efficiency synthesis method of methyl 4-piperidineacetate

The invention discloses a high-efficiency synthesis method of methyl 4-piperidineacetate. The high-efficiency synthesis method comprises the following steps: firstly, preparing a colloid; secondly, taking titanium tetrachloride, di-n-octyl ether, cetylamine and carbon disulfide as raw materials to prepare reaction liquid; adding the reaction liquid into the colloid and dropwise adding ammonia water for precipitating to prepare a catalyst; taking 4-picolinic acid as a raw material and preparing 4-nipecotic acid under the reaction of the catalyst; taking the 4-nipecotic acid as the raw materialto prepare the methyl 4-piperidineacetate. The method has the advantages of simple operation, low preparation cost, high yield of a target product and easiness in separation.

Synthesis, biological evaluation and SAR studies of benzimidazole derivatives as H1-antihistamine agents

A series of benzimidazole derivatives have been designed, synthesized and evaluated for H1 antihistamine activity. Six compounds have showed potent antihistamine H1 activity. The primary SAR analysis indicated that benzyl or benzylidinyl substituted on the exo-nitrogen atom and C2 of the benzimidazole were significant. Further experiments indicated that compound 17d displayed excellent activity to reduce mast cell degranulation, moderate anti-PAF activity and decreased potency on hERG compared to astermizole. Hence compound 17d could serve as anti-allergic agent for further development.