Technology Process of 1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone,
10-[(3-chloro-4-methoxyphenyl)methyl]-16-[(1R,2E)-3-(2,5-dimethylphen
yl)-1-methyl-2-propenyl]-6,6-dimethyl-3-(2-methylpropyl)-,
(3S,10R,13E,16S)-
There total 4 articles about 1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone,
10-[(3-chloro-4-methoxyphenyl)methyl]-16-[(1R,2E)-3-(2,5-dimethylphen
yl)-1-methyl-2-propenyl]-6,6-dimethyl-3-(2-methylpropyl)-,
(3S,10R,13E,16S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,5-dimethylbenzyl triphenylphosphonium chloride;
With
n-butyllithium;
In
tetrahydrofuran;
at -50 - 20 ℃;
cyclo[2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6S)-5-hydroxy-6-methyl-7-oxo-2-heptenoyl-3-chloro-O-methyl-D-tyrosyl];
In
tetrahydrofuran;
at -78 - 20 ℃;
With
thiophenol; 1,1'-azobis(1-cyanocyclohexanenitrile);
In
benzene;
Heating;
DOI:10.1021/jm0203884
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: m-chloroperbenzoic acid / CH2Cl2 / 20 °C
2.1: 72 percent / aq. perchloric acid / 1,2-dimethoxy-ethane / 6 h / 20 °C
3.1: 98 percent / aq. NaIO4 / tetrahydrofuran / 20 °C
4.1: n-butyllithium / tetrahydrofuran / -50 - 20 °C
4.2: tetrahydrofuran / -78 - 20 °C
4.3: 75 percent / 1,1'-azobis(cyclohexanecarbonitrile); thiophenol / benzene / Heating
With
sodium periodate; n-butyllithium; perchloric acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
4.2: Wittig reaction;
DOI:10.1021/jm0203884
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 72 percent / aq. perchloric acid / 1,2-dimethoxy-ethane / 6 h / 20 °C
2.1: 98 percent / aq. NaIO4 / tetrahydrofuran / 20 °C
3.1: n-butyllithium / tetrahydrofuran / -50 - 20 °C
3.2: tetrahydrofuran / -78 - 20 °C
3.3: 75 percent / 1,1'-azobis(cyclohexanecarbonitrile); thiophenol / benzene / Heating
With
sodium periodate; n-butyllithium; perchloric acid;
In
tetrahydrofuran; 1,2-dimethoxyethane;
3.2: Wittig reaction;
DOI:10.1021/jm0203884
