Benzeneacetic acid, 4-(methylthio)-, 1-benzoylpropyl ester

Base Information

• Chemical Name: Benzeneacetic acid, 4-(methylthio)-, 1-benzoylpropyl ester
• CAS No.: 562069-41-4
• Molecular Formula: C19H20O3S
• Molecular Weight: 328.432
• Mol file: 562069-41-4.mol

Synonyms:

Chemical Property of Benzeneacetic acid, 4-(methylthio)-, 1-benzoylpropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, 4-(methylthio)-, 1-benzoylpropyl ester

There total 2 articles about Benzeneacetic acid, 4-(methylthio)-, 1-benzoylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-(methylthio)phenyl)acetic acid (16188-55-9) + 2-bromo-1-phenylbutan-1-one (877-35-0,73908-28-8) → (4-methylsulfanyl-phenyl)-acetic acid 1-benzoyl-propyl ester (562069-41-4)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 10 - 20 ℃; for 1h;

DOI:10.1016/S0960-894X(03)00282-8

Reference yield:

propiophenone (495-40-9) → (4-methylsulfanyl-phenyl)-acetic acid 1-benzoyl-propyl ester (562069-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂; HBr / acetic acid

2: KOH / dimethylformamide / 1 h / 10 - 20 °C

With potassium hydroxide; hydrogen bromide; bromine; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(03)00282-8

Reference yield: 35.0%

(4-methylsulfanyl-phenyl)-acetic acid 1-benzoyl-propyl ester (562069-41-4) → 5-ethyl-5-hydroxy-3-(4-methylsulfanylphenyl)-4-phenyl-2,5-dihydro-2-furanone (503174-32-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 10 - 15 ℃; for 0.5h;

upstream raw materials:

2-(4-(methylthio)phenyl)acetic acid

2-bromo-1-phenylbutan-1-one

propiophenone

Downstream raw materials:

5-ethyl-3-(4-methylsulfanyl-phenyl)-4-phenyl-5H-furan-2-one

5-ethyl-5-hydroxy-3-(4-methylsulfanylphenyl)-4-phenyl-2,5-dihydro-2-furanone