1H-Pyrazole, 1-(2,4-difluorophenyl)-

Base Information

• Chemical Name: 1H-Pyrazole, 1-(2,4-difluorophenyl)-
• CAS No.: 562099-15-4
• Molecular Formula: C9H6F2N2
• Molecular Weight: 180.157
• Mol file: 562099-15-4.mol

Synonyms:

Chemical Property of 1H-Pyrazole, 1-(2,4-difluorophenyl)-

Chemical Property:

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrazole, 1-(2,4-difluorophenyl)-

There total 4 articles about 1H-Pyrazole, 1-(2,4-difluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

malonaldehydebis(dimethylacetal) (102-52-3) + (2,4-difluorophenyl)hydrazinium chloride (40594-29-4,51523-79-6) → 1-(2,4-difluorophenyl)-1H-pyrazole (562099-15-4)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 24h; Reflux;

DOI:10.1021/cm100993j

Reference yield: 13.0%

NH-pyrazole (288-13-1) + 2,4-difluoro-1-iodobenzene (2265-93-2) → 1-(2,4-difluorophenyl)-1H-pyrazole (562099-15-4) + 1-(3-fluoro-4-iodophenyl)-1H-pyrazole (1114295-45-2) + 3,4-di(1H-pyrazol-1-yl)fluorobenzene (1114295-63-4) + 1,2,4-tris(1H-pyrazol-1-yl)benzene (1114295-65-6)

Guidance literature:

With copper(I) oxide; salicylaldehyde-oxime; caesium carbonate; In acetonitrile; at 80 ℃; for 12h; regioselective reaction;

DOI:10.1016/j.tet.2008.11.036

Reference yield:

NH-pyrazole (288-13-1) → 1-(2,4-difluorophenyl)-1H-pyrazole (562099-15-4)

Guidance literature:

With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 90 ℃;

DOI:10.1016/j.bmcl.2013.08.010

upstream raw materials:

malonaldehydebis(dimethylacetal)

(2,4-difluorophenyl)hydrazinium chloride

NH-pyrazole

2,4-difluoro-1-iodobenzene

Downstream raw materials:

1-(2,4-difluorophenyl)-1H-pyrazole-4-carbaldehyde

C₂₁H₂₁F₂N₇

Refernces

Tris-heteroleptic Iridium Complexes Based on Cyclometalated Ligands with Different Cores

10.1021/acs.inorgchem.7b01307

The research focuses on the synthesis and characterization of a series of tris-heteroleptic iridium complexes based on cyclometalated ligands with different cores, specifically [Ir(C^N1)(C^N2)(acac)] complexes, where C^N1 and C^N2 are 2-phenylpyridine (ppy), 2-(2,4-difluorophenyl)pyridine (dFppy), 1-phenylpyrazole (ppz), and 1-(2,4-difluorophenyl)pyrazole (dFppz). The purpose of this study was to explore how the structure of these complexes, particularly the positioning of substituents, affects their photophysical and electrochemical properties. The researchers found that while the overall architecture of the complex primarily dictates static properties such as absorption and emission spectra and redox potentials, dynamic properties like excited-state lifetime and radiative and nonradiative rate constants are sensitive to the specific positioning of the substituents.