102-52-3

Basic information

• Product Name: 1,1,3,3-Tetramethoxypropane
• Synonyms: 1,1,3,3-tetramethoxy-propan;Malonaldehydebiscdimethyacetal;Tetramethoxypropane;TMOP;MALONALDEHYDE BIS(DIMETHYL ACETAL);MALONALDEHYDE TETRAMETHYLACETAL;MALONALDEHYDE TETRAMETHYL DIACETAL;MALONDIALDEHYDE BIS(DIMETHYL ACETAL)
• CAS NO: 102-52-3
• Molecular Formula: C₇H₁₆O₄
• Molecular Weight: 164.2
• EINECS: 203-037-2
• Product Categories: Fine Chemicals;Intermediates;Pyridines ,Halogenated Heterocycles
• Mol File: 102-52-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 183 °C(lit.)
• Flash Point: 130 °F
• Appearance: Clear colorless to yellow-brown/Liquid
• Density: 0.997 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.658mmHg at 25°C
• Refractive Index: n20/D 1.407(lit.)
• Storage Temp.: Store below +30°C.
• Water Solubility: IMMISCIBLE
• Sensitive: Moisture Sensitive
• BRN: 1700020
• CAS DataBase Reference: 1,1,3,3-Tetramethoxypropane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,3,3-Tetramethoxypropane(102-52-3)
• EPA Substance Registry System: 1,1,3,3-Tetramethoxypropane(102-52-3)

Safety Data

• Hazard Codes: F
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 1
• F: 21
• TSCA: Yes
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 102-52-3(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless to yellow-brown liquid

Uses

Different sources of media describe the Uses of 102-52-3 differently. You can refer to the following data:
1. Organic synthesis.
2. 1,1,3,3-Tetramethoxypropane was used in preparing malondialdehyde standards during malondialdehyde assay on lung homogenates. It was used to study the effect of Salvianolic acid A on the migration and proliferation of vascular smooth muscle cells.

General Description

1,1,3,3-Tetramethoxypropane undergoes acid hydrolysis to yield malondialdehyde.

InChI:InChI=1/C7H16O4/c1-6(8-2)7(9-3,10-4)11-5/h6H,1-5H3

Synthetic route

methoxyethene (107-25-5) + trimethyl orthoformate (149-73-5) → malonaldehydebis(dimethylacetal) (102-52-3) + 1,1,3,5,5-pentamethoxy-pentane (55546-58-2)

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at -78℃; for 6h;	A 65% B 8%

methanol (67-56-1) + cyclohexa-1,4-diene (1165952-92-0) → methyl 3,3-dimethoxypropionate (7424-91-1) + malonaldehydebis(dimethylacetal) (102-52-3) + malonic acid dimethyl ester (108-59-8)

Conditions	Yield
With hydrogenchloride; ozone -40 deg C, then ca. 30 min reflux; Yields of byproduct given;	A 60% B n/a C n/a
With hydrogenchloride; ozone at -40℃; -40 deg C, then ca. 30 min reflux; Yield given;	A 60% B n/a C n/a
With hydrogenchloride; ozone at -40℃; Product distribution;	A 60% B n/a C n/a

vinyl acetate (108-05-4) + trimethyl orthoformate (149-73-5) → malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
With iron(III) chloride; sodium hydrogencarbonate 1) 2 h, reflux; 2) 20 deg C, 2 h;	36%
With iron(III) chloride at 60℃;

methanol (67-56-1) + 1,1,3-trimethoxy-3-acethoxypropane (98561-07-0) → malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
With boron fluoride ether

methoxyethene (107-25-5) + trifluoroborane diethyl ether (109-63-7) + trimethyl orthoformate (149-73-5) → 1-ethoxy-1,3,3-trimethoxypropane (123-59-1) + malonaldehydebis(dimethylacetal) (102-52-3)

methoxyethene (107-25-5) + trimethyl orthoformate (149-73-5) → malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
With boron fluoride ether
at 84℃; under 37.5038 Torr; for 1h; Reactivity; Gas phase;
With boron trifluoride diethyl etherate Reactivity; Gas phase;
With boron fluoride ether

methanol (67-56-1) + Propargylic aldehyde (624-67-9) → malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
(i) N-methylpiperidine, (ii) HCl; Multistep reaction;

methanol (67-56-1) + 3-phenoxy-propenal (2862-47-7) → malonaldehydebis(dimethylacetal) (102-52-3)

methanol (67-56-1) + 3,3-dimethoxypropanal (19060-10-7) → malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
With hydrogenchloride

methanol (67-56-1) + (Z)-1,1,6,6-Tetramethoxy-3-hexen (123331-77-1) → methyl 3,3-dimethoxypropionate (7424-91-1) + malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
With hydrogenchloride; ozone 1.) -40 deg C, 2.) reflux, 1 h; Yield given. Multistep reaction;
With hydrogenchloride; reflux; ozone

methanol (67-56-1) + cyclopenta-1,3-diene (542-92-7) → malonaldehydebis(dimethylacetal) (102-52-3) + methyl 3-oxopropionate (63857-17-0) + 3t-methoxy-propenal (78923-06-5) + 3,3-dimethoxypropanal (19060-10-7)

Conditions	Yield
With 2,3-dimercapto-succinic acid; ozone 1) -78 deg C; Yield given. Multistep reaction. Yields of byproduct given;
With 2,3-dimercapto-succinic acid; ozone 1) -78 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

linoleic acid (60-33-3) → malonaldehydebis(dimethylacetal) (102-52-3) + acrolein (107-02-8)

Conditions	Yield
With ozone In various solvent(s) for 0.5h; pH=8; Product distribution; Oxidation;

all cis 5,8,11,14-eicosatetraenoic acid (506-32-1) → malonaldehydebis(dimethylacetal) (102-52-3) + acrolein (107-02-8)

Conditions	Yield
With ozone In various solvent(s) for 0.5h; pH=8; Product distribution; Oxidation;

vinyl acetate (108-05-4) + iron(III) chloride (7705-08-0) + trimethyl orthoformate (149-73-5) → malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
at 60℃; reagiert analog mit Orthoameisensaeure-triaethylester in Gegenwart von FeCl3, AlCl3, SnCl2 oder SnCl4;
at 60℃;

methanol (67-56-1) + 1,1,diacetoxy-3,3-dimethoxy-propane → malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
With boron fluoride ether

methanol (67-56-1) + 1,5-dimethylcyclohexa-1,4-diene (4190-06-1) → malonaldehydebis(dimethylacetal) (102-52-3) + 3,5-dimethoxy-[1,2]dioxolane + 3,5-dimethoxy-3,5-dimethyl-[1,2]dioxolane

Conditions	Yield
With toluene-4-sulfonic acid; ozone In dichloromethane at -78℃; Title compound not separated from byproducts;	A 10 % Spectr. B 15 % Spectr. C 75 % Spectr.

methanol (67-56-1) + acrolein (107-02-8) → malonaldehydebis(dimethylacetal) (102-52-3) + 1,1,3-trimethoxypropane (14315-97-0) + 3-methoxy-1-propanal (2806-84-0)

Conditions	Yield
With carbon dioxide; oxygen; sodium phosphate; copper(l) chloride; palladium dichloride at 50℃; under 90007.2 Torr; for 24h; Michael addition;	A 17.5 % Chromat. B 54.6 % Chromat. C 26.2 % Chromat.

methanol (67-56-1) + acrolein (107-02-8) → malonaldehydebis(dimethylacetal) (102-52-3) + 1,1,3-trimethoxypropane (14315-97-0) + 3-methoxy-1-propanal (2806-84-0) + 3,3-dimethoxypropanal (19060-10-7)

Conditions	Yield
With carbon dioxide; polystyrene-supported benzoquinone; oxygen; palladium dichloride at 50℃; under 67505.4 Torr; for 12h;	A 46.7 % Chromat. B 12.9 % Chromat. C 3.9 % Chromat. D 20.4 % Chromat.

vinyl acetate (108-05-4) + trimethyl orthoformate (149-73-5) → malonaldehydebis(dimethylacetal) (102-52-3) + 1,1,3-trimethoxy-3-acethoxypropane (98561-07-0)

Conditions	Yield
at 80℃; for 1h; Gas phase;
With boron trifluoride diethyl etherate at 80℃; under 22.5023 Torr; for 1h; Reactivity; Gas phase;

vinyl acetate (108-05-4) + trimethyl orthoformate (149-73-5) → malonaldehydebis(dimethylacetal) (102-52-3) + 1,1,3-trimethoxy-3-acethoxypropane (98561-07-0) + 1,3-diacetoxy-1,3-dimethoxy-propane (15874-25-6)

Conditions	Yield
With p-benzoquinone; PtCl2(PhCN)2 at 30℃; for 24h;
With p-benzoquinone at 30℃; for 2h;
With p-benzoquinone at 30℃; for 2.3h;
With p-benzoquinone for 2h;

isobutyl vinyl ether (109-53-5) + trimethyl orthoformate (149-73-5) → 1,3,3-trimethoxy-1-(isobutoxy)propane + malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
Stage #1: isobutyl vinyl ether; trimethyl orthoformate; iron(III) chloride at -5 - 20℃; Stage #2: With sodium carbonate

vinyl isopropyl ether (926-65-8) + trimethyl orthoformate (149-73-5) → malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
iron(III) chloride at -15℃; for 7h; Product distribution / selectivity;
iron(III) chloride at 2℃; for 7h; Product distribution / selectivity;
iron(III) chloride at 35℃; for 7h; Product distribution / selectivity;

vinyl isopropyl ether (926-65-8) + trimethyl orthoformate (149-73-5) → 1,3,3-trimethoxy-1-(isopropoxy)propane (603151-66-2) + malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
Stage #1: vinyl isopropyl ether; trimethyl orthoformate; iron(III) chloride at -5 - 20℃; Stage #2: With sodium carbonate

-butyl vinyl ether (111-34-2) + trimethyl orthoformate (149-73-5) → 1,3,3-trimethoxy-1-(n-butoxy)propane (768388-22-3) + malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
Stage #1: -butyl vinyl ether; trimethyl orthoformate; iron(III) chloride at -5 - 20℃; Stage #2: With sodium carbonate

vinyl propyl ether (764-47-6) + trimethyl orthoformate (149-73-5) → 1,3,3-trimethoxy-1-(n-propoxy)propane (603151-65-1) + malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
Stage #1: vinyl propyl ether; trimethyl orthoformate; iron(III) chloride at -5 - 20℃; Stage #2: With sodium carbonate

5-Amino-1,3-dimethylpyrazole (3524-32-1) + malonaldehydebis(dimethylacetal) (102-52-3) → 1,3-dimethylpyrazolo<3,4-b>pyridine (116834-97-0)

Conditions	Yield
zinc(II) chloride In hydrogenchloride; ethanol for 1h; Heating;	100%

malonaldehydebis(dimethylacetal) (102-52-3) + methyl 2-chloro-3-hydrazinylbenzoate hydrochloride (1143025-56-2) → methyl 2-chloro-3-(1H-pyrazol-1-yl)benzoate (1143025-57-3)

Conditions	Yield
In ethanol at 80℃; for 2h;	100%
In ethanol at 80℃; for 2h;	100%

malonaldehydebis(dimethylacetal) (102-52-3) + 5-aminoimidazole-4-carboxamide hydrochloride (72-40-2) → C7H6N4O

Conditions	Yield
In ethanol at 100℃; for 20h; Autoclave;	100%

malonaldehydebis(dimethylacetal) (102-52-3) + N-methylaniline (100-61-8) → 3-(N-Methylanilino)-2-propenal (14189-82-3)

Conditions	Yield
Stage #1: malonaldehydebis(dimethylacetal); N-methylaniline at 30℃; for 0.166667h; Stage #2: With hydrogenchloride In water at 24℃; for 2.5h; Temperature;	99.6%

malonaldehydebis(dimethylacetal) (102-52-3) + trimethylsilyl cyanide (7677-24-9) → 2,4,4-trimethoxybutanenitrile (112890-36-5)

Conditions	Yield
With boron trifluoride diethyl etherate at 0℃; for 3h;	99%
With boron trifluoride diethyl etherate at 0℃; for 3h; Inert atmosphere; Neat (no solvent);	92%
With boron trifluoride diethyl etherate at 0℃; for 3h;

malonaldehydebis(dimethylacetal) (102-52-3) + nickel(II) acetate tetrahydrate (6018-89-9) + 4,5-dimethyl-1,2-phenylenediamine (3171-45-7) → {7,16-dihydro-2,3,11,12-tetramethyldibenzo{b,i}{1,4,8,11}tetraazacyclotetradecinato-N5,N9,N14,N18}nickel(II) (57574-24-0)

Conditions	Yield
In water; N,N-dimethyl-formamide reflux for 10 h; filtn., chromy.; elem. anal.;;	99%

malonaldehydebis(dimethylacetal) (102-52-3) + C24H24N4O → C27H24N4O

Conditions	Yield
With acetic acid at 110℃; for 16h;	99%

malonaldehydebis(dimethylacetal) (102-52-3) + phenylhydrazine (100-63-0) → 1-phenylpyrazole (1126-00-7)

Conditions	Yield
With hydrogenchloride In ethanol at 60℃; for 4h;	98%
With hydrogenchloride In ethanol for 1h; Heating;	93%
With hydrogenchloride In methanol for 1h; Reflux;	90%
With hydrogenchloride; water In ethanol for 4h; Reflux;	85%
With hydrogenchloride In ethanol; water Heating;

N-(3-isopropoxy-propyl)-3-cyano-4-methyl-2-pyridone (1267247-06-2) + malonaldehydebis(dimethylacetal) (102-52-3) → C29H35N4O6(1-)

Conditions	Yield
In ethanol for 21h; Heating / reflux;	98%

1-butyl-4-methyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile (137996-30-6) + malonaldehydebis(dimethylacetal) (102-52-3) → C25H27N4O4(1-)*K(1+) (927811-20-9)

Conditions	Yield
With potassium acetate In butan-1-ol at 100 - 110℃; for 4.5h; Heating / reflux;	98%

(2-chloro-4-fluorophenyl)hydrazine + malonaldehydebis(dimethylacetal) (102-52-3) → 1-(2-chloro-4-fluorophenyl)-1H-pyrazole

Conditions	Yield
With hydrogenchloride In ethanol; water at 90℃; for 16h;	98%

1-phenylpyrazol-5-amine (826-85-7) + malonaldehydebis(dimethylacetal) (102-52-3) → 1-phenyl-1H-pyrazolo[3,4-b]pyridine (20208-81-5)

Conditions	Yield
zinc(II) chloride In hydrogenchloride; ethanol for 1h; Heating;	97%

malonaldehydebis(dimethylacetal) (102-52-3) + 2,2-Dimethyl-1,3-propanediol (126-30-7) → bis(5,5-dimethyl-1,3-dioxan-2-yl)-methane (30859-70-2)

Conditions	Yield
With hydrogenchloride at 140℃; for 0.5h;	97%
With o-toluenesulfonic acid In toluene	85%
With toluene-4-sulfonic acid In toluene Heating;	85%
With toluene-4-sulfonic acid In toluene at 80 - 90℃;

malonaldehydebis(dimethylacetal) (102-52-3) + 5-chloro-2-nitrophenylhydrazine (1966-16-1) → 1-(5-chloro-2-nitro-phenyl)-1H-pyrazole (60418-31-7)

Conditions	Yield
With sulfuric acid In ethanol; acetic acid for 6h; Heating;	97%

malonaldehydebis(dimethylacetal) (102-52-3) + (2,5-difluorophenyl)hydrazine → 1-(2,5-difluoro-phenyl)-1H-pyrazole (1143517-62-7)

Conditions	Yield
With hydrogenchloride; water In ethanol for 17h; Heating / reflux;	97%

malonaldehydebis(dimethylacetal) (102-52-3) + [14C]urea (594-05-8) → pyrimidin-2[(14)C]-ol hydrochloride (83056-70-6)

Conditions	Yield
With hydrogenchloride In ethanol at 85℃; for 1.3h;	97%

malonaldehydebis(dimethylacetal) (102-52-3) → [15N2]pyrazole (55949-00-3)

Conditions	Yield
With hydrazinium sulfate In ethanol; water at 75℃; for 2h;	96.3%
With [15N2]-hydrazinium sulfate In ethanol; water at 20 - 75℃; for 24.25h;	67%

malonaldehydebis(dimethylacetal) (102-52-3) + trimethyleneglycol (504-63-2) → di(1,3-dioxan-2-yl)methane (30963-84-9)

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 110℃; for 24h;	96%
With o-toluenesulfonic acid In toluene	92%
With toluene-4-sulfonic acid In toluene Heating;	92%

malonaldehydebis(dimethylacetal) (102-52-3) + 3-hydrazinobenzoic acid (38235-71-1) → 3-(1H-pyrazol-1-yl)benzoic acid

Conditions	Yield
In ethanol; water for 2h; Heating / reflux;	96%
In ethanol; water for 48h; Reflux;	73%
With acetic acid In water at 150℃; for 0.0833333h; Microwave irradiation;

malonaldehydebis(dimethylacetal) (102-52-3) + 2-(trifluoromethyl)phenylhydrazine (365-34-4) → 1-(2-(trifluoromethyl)phenyl)-1H-pyrazole (84401-17-2)

Conditions	Yield
With hydrogenchloride In ethanol; water at 80 - 90℃; for 3h;	96%
With hydrogenchloride In ethanol; water Heating;
With hydrogenchloride In ethanol; water at 90℃; for 3h;

malonaldehydebis(dimethylacetal) (102-52-3) + 5-pyridin-4-yl-2H-pyrazol-3-yl-amine (91912-53-7) → 2-(pyridin-4-yl)pyrazolo[1.5-a]pyrimidine (905281-89-2)

Conditions	Yield
With acetic acid at 110℃; for 16h;	96%

N-ethyl-3-cyano-4-methyl-2-pyridone (201217-33-6) + N-(3-isopropoxy-propyl)-3-cyano-4-methyl-2-pyridone (1267247-06-2) + malonaldehydebis(dimethylacetal) (102-52-3) → C25H27N4O5(1-)*K(1+)

Conditions	Yield
With potassium acetate In 4-methyl-2-pentanone at 104 - 106℃; for 3h;	95.5%

2,3-dimethyl-2,3-butane diol (76-09-5) + malonaldehydebis(dimethylacetal) (102-52-3) → 1,3-bis(4',4',5',5'-tetramethyl-1,3-dioxolan-2-yl)methane (86444-84-0)

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 1h; Heating;	95%
With toluene-4-sulfonic acid In benzene at 90℃; for 2h;	95%
With toluene-4-sulfonic acid In benzene at 90℃; for 2h; Condensation;	95%
With 4 A molecular sieve; toluene-4-sulfonic acid In benzene Heating;

malonaldehydebis(dimethylacetal) (102-52-3) + indan-1,2,3-trione hydrate (485-47-2) → (E)-3-Hydroxy-2-(2-hydroxy-1,3-dioxo-indan-2-yl)-propenal (77708-56-6)

Conditions	Yield
In water at 50 - 55℃; for 2h;	95%

malonaldehydebis(dimethylacetal) (102-52-3) + (2S,4S)-pentane-2,4-diol (72345-23-4) → malonedialdehyde bis[(S,S)-1,3-dimethylpropylene] acetal (116185-04-7)

Conditions	Yield
With o-toluenesulfonic acid In toluene	95%
With toluene-4-sulfonic acid In toluene Heating;	95%

malonaldehydebis(dimethylacetal) (102-52-3) + ethylene glycol (107-21-1) → di(1,3-dioxolan-2-yl)methane (4405-17-8)

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	95%
With o-toluenesulfonic acid In toluene

malonaldehydebis(dimethylacetal) (102-52-3) + 4-(tert-butyl)-1,2-diaminobenzene (68176-57-8) + nickel(II) acetate tetrahydrate (6018-89-9) → {7,16-dihydro-2,12-di-tert-butyldibenzo{b,i}{1,4,8,11}tetraazacyclotetradecinato-N5,N9,N14,N18}nickel(II) (96411-84-6)

Conditions	Yield
In water; N,N-dimethyl-formamide reflux for 12 h; filtn., washing (water), chromy., elem. anal.;	95%

malonaldehydebis(dimethylacetal) (102-52-3) + 4-methoxyphenylhydrazine hydrochloride (19501-58-7) → 1-(4-methoxyphenyl)-1H-pyrazole (35715-67-4)

Conditions	Yield
In ethanol for 1h; Reflux;	95%
In ethanol; water Reflux;	82.6%

4-methoxycarbonyl-2-nitrophenylhydrazine (87054-48-6) + malonaldehydebis(dimethylacetal) (102-52-3) → C11H9N3O4

Conditions	Yield
With hydrogenchloride In ethanol; water for 2.5h; Reflux;	95%

malonaldehydebis(dimethylacetal) (102-52-3) + 2-Thiobarbituric acid (91759-32-9) → C11H8N4O4S2*ClH

Conditions	Yield
With hydrogenchloride at 50 - 60℃; for 0.5h;	93%

Upstream product

• 107-25-5 methoxyethene 
• 109-63-7 trifluoroborane diethyl ether 
• 149-73-5 trimethyl orthoformate 
• 108-05-4 vinyl acetate 
• 67-56-1 methanol 
• 19060-10-7 3,3-dimethoxypropanal 
• 1165952-92-0 cyclohexa-1,4-diene 
• 60-33-3 linoleic acid 
• 7705-08-0 iron(III) chloride 
• 109-53-5 isobutyl vinyl ether 
• 764-47-6 vinyl propyl ether 
• 111-34-2 -butyl vinyl ether 
• 926-65-8 vinyl isopropyl ether 
• 107-02-8 acrolein 

Downstream Products

• 289-95-2 PYRIMIDINE 
• 57356-49-7 phenyl-pyrimidin-2-yl-amine 
• 116834-97-0 1,3-dimethylpyrazolo<3,4-b>pyridine 
• 116834-99-2 1,3-diphenyl-1H-pyrazolo[3,4-b]pyridine 
• 137044-53-2 9-hydroxy-pyrido<1,2-a>pyrimidin-5-ium perchlorate 
• 7431-45-0 2-phenylpyrimidine 
• 76211-91-1 3-nitro-2-(pyrazol-1-yl)-pyridine 
• 20577-27-9 pyrid-2-one-3-carbonitrile 
• 15992-83-3 [1,8]naphthyridin-2-ylamine 
• 191212-20-1 2-(4-chlorophenyl)pyrimidine 
• 1126-00-7 1-phenylpyrazole 
• 219580-32-2 tert-butyl 1H-pyrazole-1-carboxylate 
• 16013-14-2 3-(4-nitrophenyl)-[1,2,4]oxadiazole 

Relevant articles and documents

Identification of acrolein from the ozone oxidation of unsaturated fatty acids

By-products of lipoperoxidation reactions may be associated with the genesis or the progression of several diseases as arteriosclerosis, diabetes and cancer, among many others. Acrolein, at first a widely distributed environmental pollutant, is currently known as a compound capable of being generated as a result of metabolic reactions within biological systems, highly toxic and the most electrophilic of the α, β-unsaturated aldehydes formed during lipoperoxidation. In the present study: 1. The separation of acrolein and malondialdehyde was achieved at alkaline pH with the use of high voltage capillary electrophoresis in uncoated fused-silica capillaries. 2. It was demonstrated how the oxidation of fatty acids (arachidonic/linoleic) with ozone generates, in dose-dependent form, acrolein as one of the by-products of the lipoperoxidation process. The oxidation of open human erythrocyte membranes with ozone also generated acrolein. 3. After aldolic condensation, aldol-acrolein derivative has a positive reaction with 2-thiobarbituric acid (TBA) and shows a maximum absorption at 498 nm. This novel characteristic is used in its identification after the separation of the by-products. 4. It is possible to suggest that in the classic reaction of the denominated thiobarbituric acid reactive substances (TBARS), when used as an indicator of the degree of peroxidation in biological systems, a portion of acrolein could be present but dwarfed by the TBA-MDA adduct.

PROCESS FOR PRODUCING TETRAALKOXYPROPANE AND DERIVATIVE THEREOF

In view of the fact that a methyl vinyl ether, which is useful as a starting material for the synthesis of tetraalkoxypropane useful as a skeleton-forming agent having a high reactivity usable as a starting material, etc. for a pharmaceutical and agrochemical intermediates such as a pyrazole derivative or pyrimidine derivative, particularly 1,1,3,3-tetramethoxypropane, is in a gaseous state and difficult to use for industrial production, tetraalkoxypropane useful as a skeleton-forming agent for a pharmaceutical and agrochemical intermediate such as a pyrazole derivative or pyrimidine derivative is easily produced on an industrial scale by using the industrially useable propoxyvinyl ether, as a starting material, without using a gaseous state methyl vinyl ether.

Process for preparing acetals of malondialdehyde

A process directed to the preparation of acetals of malondialdehyde by reacting alkylvinyl ethers or esters with ortho formates in the gas phase with a heterogeneous catalyst.