Novobiocin

Base Information Edit

Chemical Name:Novobiocin
CAS No.:303-81-1
Molecular Formula:C₃₁H₃₆N₂O₁₁
Molecular Weight:612.634
Hs Code.:2941906000
Mol file:303-81-1.mol

Synonyms:Benzamide,N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-a-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-(9CI); Coumarin, 7-[4-(carbamoyloxy)tetrahydro-3-hydroxy-5-methoxy-6,6-dimethylpyran-2-yloxy]-4-hydroxy-3-[4-hydroxy-3-(3-methyl-2-butenyl)benzamido]-8-methyl-(6CI); Novobiocin (8CI); Albamix; Albamycin; Antibiotic PA-93; Cardelmycin;Cathocin; Cathomycin; Crystallinic acid; Inamycin; Novo-R; PA 93; Robiocina; Sirbiocina;Spheromycin; Stilbiocina; Streptonivicin; U 6391

Suppliers and Price of Novobiocin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Novobiocin
5mg
$ 362.00

TRC
Novobiocin
500mg
$ 805.00

TRC
Novobiocin
100mg
$ 180.00

TRC
Novobiocin
25mg
$ 90.00

Sigma-Aldrich
Novobiocin
200mg
$ 350.00

American Custom Chemicals Corporation
NOVOBIOCIN 90.00%
5MG
$ 1706.75

American Custom Chemicals Corporation
NOVOBIOCIN 90.00%
1MG
$ 997.50

AK Scientific
Novobiocin
25mg
$ 239.00

Total 28 raw suppliers

Chemical Property of Novobiocin Edit

Chemical Property:

Melting Point:170-172 °C
Refractive Index:1.5800 (estimate)
Boiling Point:848.2°Cat760mmHg
PKA:pKa1 4.3; pKa2 9.1(at 25℃)
Flash Point:466.8°C
PSA：200.01000
Density:1.42g/cm³
LogP:4.40040
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Novobiocin ^*data from reagent suppliers

Safty Information:

Pictogram(s): May have damaging side effects.
Hazard Codes:May have damaging side effects.

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Description Novobiocin (Albamycin, Cathamycin, Spheromycin) is an aminocoumarin antibiotic originally isolated from Streptomyces niveus in the Upjohn Research Laboratories and initially was given the generic name of ‘streptonivicin’ . It was also isolated almost simultaneously in other laboratories, and was given several other names. Novobiocin inhibits the GyrB subunit of DNA gyrase and is primarily active against Gram-positive microorganisms. It was used under the trade name Albamycin and was withdrawn from the market in the US. Its latest use included eradication of methicillin-resistant Staphylococcus aureus (MRSA) and other resistant microorganisms. In addition, it has been applied in cancer therapy.
Uses Novobiocin is an aminocoumarin antibiotic isolated from a number of species of Streptomyces. Novobiocin exhibits broad spectrum Gram positive activity and was used clinically. Novobiocin is a potent inhibitor of bacterial DNA gyrase and a competitive inhibitor of the ATPase reaction catalysed by GyrB. Novobiocin is an aminocoumarin antibiotic used in the treatment of Staphylococcus epidermis.
Therapeutic Function Antibiotic
Clinical Use Novobiocin formerly had a role in the treatment of staphylococcal infections. With the advent of the penicillinase-resistant penicillins and other anti-staphylococcal agents, novobiocin is no longer used for this indication, except perhaps as an adjunct to other drugs for the treatment of methicillin-resistant staphylococcal infections. For instance, novobiocin/sodium fusidate and novobiocin/rifampicin combinations have been used successfully to treat staphylococcal infections of this nature.

Technology Process of Novobiocin

There total 4 articles about Novobiocin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%