1-Piperidinecarboxylic acid, 3-[(acetyloxy)imino]-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 3-[(acetyloxy)imino]-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
CAS No.:562817-62-3
Molecular Formula:C18H24N2O4
Molecular Weight:332.4
Hs Code.:

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 3-[(acetyloxy)imino]-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

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Technology Process of 1-Piperidinecarboxylic acid, 3-[(acetyloxy)imino]-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

There total 6 articles about 1-Piperidinecarboxylic acid, 3-[(acetyloxy)imino]-2-phenyl-, 1,1-dimethylethyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 562817-59-8
(2S,3S)-3-hydroxy-1-(4-methoxybenzyl)-2-phenylpiperidine

: 562817-62-3
C₁₈H₂₄N₂O₄

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / H₂ / Pd(OH)2/C / ethanol / 72 h / 20 °C

2: oxalyl chloride; dimethylsulfoxide; diisopropylethylamine / CH₂Cl₂ / -78 - -20 °C

3: 430 mg / hydroxylamine hydrochloride; potassium carbonate / CH₂Cl₂ / 5 h / -20 °C

4: tetrahydrofuran / 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; hydrogen; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; 2: Swern oxidation;
DOI:10.1021/ol034505g

Reference yield:

: 562817-58-7
(-)-(5S,6S)-5-hydroxy-1-(4-methoxybenzyl)-6-phenyl-5,6-dihydropyridin-2(1H)-one

: 562817-62-3
C₁₈H₂₄N₂O₄

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / 20 °C

2: 88 percent / H₂ / Pd(OH)2/C / ethanol / 72 h / 20 °C

3: oxalyl chloride; dimethylsulfoxide; diisopropylethylamine / CH₂Cl₂ / -78 - -20 °C

4: 430 mg / hydroxylamine hydrochloride; potassium carbonate / CH₂Cl₂ / 5 h / -20 °C

5: tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; hydroxylamine hydrochloride; hydrogen; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; 3: Swern oxidation;
DOI:10.1021/ol034505g

Reference yield:

: (5S,6RS)-5-[(tert-butyldiphenylsilyl)oxy]-6-hydroxy-1-(4-methoxybenzyl)-2-piperidone

: 562817-62-3
C₁₈H₂₄N₂O₄

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / BF₃*Et₂O / CH₂Cl₂ / 72 h / 20 °C

2: 81 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / 20 °C

3: 88 percent / H₂ / Pd(OH)2/C / ethanol / 72 h / 20 °C

4: oxalyl chloride; dimethylsulfoxide; diisopropylethylamine / CH₂Cl₂ / -78 - -20 °C

5: 430 mg / hydroxylamine hydrochloride; potassium carbonate / CH₂Cl₂ / 5 h / -20 °C

6: tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; hydrogen; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; 4: Swern oxidation;
DOI:10.1021/ol034505g