3-Thymidylic acid, N-benzoyl-5-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2-deoxycytidylyl-(3.5)-, 2-chlorophenyl 2-cyanoethyl ester

Base Information

• Chemical Name: 3-Thymidylic acid, N-benzoyl-5-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2-deoxycytidylyl-(3.5)-, 2-chlorophenyl 2-cyanoethyl ester
• CAS No.: 78129-28-9
• Molecular Formula: C₆₂H₅₈Cl₂N₆O₁₇P₂
• Molecular Weight: 1292.03
• Mol file: 78129-28-9.mol

Synonyms:

Chemical Property of 3-Thymidylic acid, N-benzoyl-5-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2-deoxycytidylyl-(3.5)-, 2-chlorophenyl 2-cyanoethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Thymidylic acid, N-benzoyl-5-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2-deoxycytidylyl-(3.5)-, 2-chlorophenyl 2-cyanoethyl ester

There total 7 articles about 3-Thymidylic acid, N-benzoyl-5-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2-deoxycytidylyl-(3.5)-, 2-chlorophenyl 2-cyanoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) → C62H58Cl2N6O17P2 (78129-28-9)

Guidance literature:

Multi-step reaction with 4 steps

2: 1-methyl imidazole

3: 2 percent BSA

4: mesitylenesulfonyl-3-nitrotriazolide

With 1-methyl-1H-imidazole; benzenesulfonamide; mesitylenesulfonyl-3-nitrotriazolide;

DOI:10.1248/cpb.34.2202

Reference yield:

[1,2,4]Triazol-1-yl-phosphonic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (76964-04-0) → C62H58Cl2N6O17P2 (78129-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O / pyridine

2: mesitylenesulfonyl-3-nitrotriazolide

With mesitylenesulfonyl-3-nitrotriazolide; water; In pyridine;

DOI:10.1248/cpb.34.2202

Reference yield:

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) → C62H58Cl2N6O17P2 (78129-28-9)

Guidance literature:

Multi-step reaction with 3 steps

2: H₂O / pyridine

3: mesitylenesulfonyl-3-nitrotriazolide

With mesitylenesulfonyl-3-nitrotriazolide; water; In pyridine;

DOI:10.1248/cpb.34.2202

upstream raw materials:

2'-deoxythymidine-3'-O-(2-chlorophenyl-2-cyanoethyl)phosphate

5'-O-(dimethoxytrityl)thymidine 3'-(o-chlorophenyl β-cyanoethyl phosphate)

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

[1,2,4]Triazol-1-yl-phosphonic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Downstream raw materials:

C₅₉H₅₅Cl₂N₅O₁₇P₂*C₆H₁₅N

Refernces