6-Amino-2,3-dimethylbenzoic acid

Base Information

• Chemical Name: 6-Amino-2,3-dimethylbenzoic acid
• CAS No.: 5628-48-8
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Mol file: 5628-48-8.mol

Synonyms:5,6-Dimethylanthranilic acid;Benzoic acid, 6-amino-2,3-dimethyl-;2-Amino-5,6-dimethylbenzoic acid;Anthranilic acid, 5,6-dimethyl- (7CI,8CI);

Chemical Property of 6-Amino-2,3-dimethylbenzoic acid

Chemical Property:

• Melting Point: 140-141 °C (decomp)
• Boiling Point: 328.4±30.0 °C(Predicted)
• PKA: 2.02±0.31(Predicted)
• PSA: 63.32000
• Density: 1?+-.0.06 g/cm3(Predicted)
• LogP: 2.16500

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Amino-2,3-dimethylbenzoic acid

There total 4 articles about 6-Amino-2,3-dimethylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

4,5-dimethylisatin (100487-79-4) → 4,5-dimethylanthranilic acid (5628-48-8)

Guidance literature:

4,5-dimethylisatin; With sodium hydroxide; dihydrogen peroxide; In water; at 85 ℃; for 2h;

With sulfuric acid; at 20 ℃; pH=1;

Reference yield:

4-amino-o-xylene (95-64-7) → 4,5-dimethylanthranilic acid (5628-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Na₂SO₄; aqueous HCl; NH₂OH+HCl

2: sulfuric acid

3: aqueous NaOH; H₂O₂

With hydrogenchloride; sodium hydroxide; sulfuric acid; hydroxylamine; dihydrogen peroxide; sodium sulfate;

DOI:10.1021/jo01135a015

Reference yield:

hydroxyimino-acetic acid-(3,4-dimethyl-anilide) (17122-69-9) → 4,5-dimethylanthranilic acid (5628-48-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid

2: aqueous NaOH; H₂O₂

With sodium hydroxide; sulfuric acid; dihydrogen peroxide;

DOI:10.1021/jo01135a015

upstream raw materials:

4,5-dimethylisatin

hydroxyimino-acetic acid-(3,4-dimethyl-anilide)

4-amino-o-xylene