1,3-Dioxa-7-azaspiro[4.4]nonane-7-carboxylic acid, 8-benzoyl-4-ethyl-8-hydroxy-2,2-dimethyl-6-oxo-9-(phenylmethoxy)-, 1,1-dimethylethyl ester, (4S,5R,9R)-

Base Information

Chemical Name:1,3-Dioxa-7-azaspiro[4.4]nonane-7-carboxylic acid, 8-benzoyl-4-ethyl-8-hydroxy-2,2-dimethyl-6-oxo-9-(phenylmethoxy)-, 1,1-dimethylethyl ester, (4S,5R,9R)-
CAS No.:562858-26-8
Molecular Formula:C₂₉H₃₅NO₈
Molecular Weight:525.599
Hs Code.:

1,3-Dioxa-7-azaspiro[4.4]nonane-7-carboxylic acid,
8-benzoyl-4-ethyl-8-hydroxy-2,2-dimethyl-6-oxo-9-(phenylmethoxy)-,
1,1-dimethylethyl ester, (4S,5R,9R)-

Synonyms:

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Chemical Property of 1,3-Dioxa-7-azaspiro[4.4]nonane-7-carboxylic acid, 8-benzoyl-4-ethyl-8-hydroxy-2,2-dimethyl-6-oxo-9-(phenylmethoxy)-, 1,1-dimethylethyl ester, (4S,5R,9R)-

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Technology Process of 1,3-Dioxa-7-azaspiro[4.4]nonane-7-carboxylic acid, 8-benzoyl-4-ethyl-8-hydroxy-2,2-dimethyl-6-oxo-9-(phenylmethoxy)-, 1,1-dimethylethyl ester, (4S,5R,9R)-

There total 8 articles about 1,3-Dioxa-7-azaspiro[4.4]nonane-7-carboxylic acid, 8-benzoyl-4-ethyl-8-hydroxy-2,2-dimethyl-6-oxo-9-(phenylmethoxy)-, 1,1-dimethylethyl ester, (4S,5R,9R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 562858-25-7
[(4R,5S)-4-((S)-1-Benzyloxy-3-phenyl-prop-2-ynyl)-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carbonyl]-carbamic acid tert-butyl ester

: 562858-26-8
(4S,5R,9R)-8-Benzoyl-9-benzyloxy-4-ethyl-8-hydroxy-2,2-dimethyl-6-oxo-1,3-dioxa-7-aza-spiro[4.4]nonane-7-carboxylic acid tert-butyl ester

Guidance literature:: With potassium permanganate; In water; acetone;
DOI:10.1021/ol034630s

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 562858-26-8
(4S,5R,9R)-8-Benzoyl-9-benzyloxy-4-ethyl-8-hydroxy-2,2-dimethyl-6-oxo-1,3-dioxa-7-aza-spiro[4.4]nonane-7-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: KH / dimethylformamide

2: KMnO₄ / acetone; H₂O

With potassium permanganate; potassium hydride; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol034630s

Reference yield:

: 100-39-0
benzyl bromide

: 562858-26-8
(4S,5R,9R)-8-Benzoyl-9-benzyloxy-4-ethyl-8-hydroxy-2,2-dimethyl-6-oxo-1,3-dioxa-7-aza-spiro[4.4]nonane-7-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / dimethylformamide

2: 3 N LiOH / 2-methyl-propan-2-ol / 110 °C

3: (COCl)2; triethylamine; DMF / CH₂Cl₂

4: ammonia

5: KH / dimethylformamide

6: KMnO₄ / acetone; H₂O

With lithium hydroxide; potassium permanganate; oxalyl dichloride; ammonia; potassium hydride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1021/ol034630s