Acetamide, N-[(1S)-1-ethenyl-3-methylbutyl]-2,2,2-trifluoro-N-(4-methoxyphenyl)-

Base Information

• Chemical Name: Acetamide, N-[(1S)-1-ethenyl-3-methylbutyl]-2,2,2-trifluoro-N-(4-methoxyphenyl)-
• CAS No.: 562870-89-7
• Molecular Formula: C16H20F3NO2
• Molecular Weight: 315.336
• Mol file: 562870-89-7.mol

Synonyms:

Chemical Property of Acetamide, N-[(1S)-1-ethenyl-3-methylbutyl]-2,2,2-trifluoro-N-(4-methoxyphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetamide, N-[(1S)-1-ethenyl-3-methylbutyl]-2,2,2-trifluoro-N-(4-methoxyphenyl)-

There total 8 articles about Acetamide, N-[(1S)-1-ethenyl-3-methylbutyl]-2,2,2-trifluoro-N-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidic acid 5-methyl-hex-2-enyl ester → (S)-2,2,2-trifluoro-N-(4-methoxyphenyl)-N-(1-isobutylallyl)acetamide (562870-89-7)

Guidance literature:

With C₁₀₈H₈₈Cl₄Fe₂N₈O₈Pd₂Pt₂S₄; C₁₀₈H₈₈Cl₄Fe₂N₈O₈Pd₂Pt₂S₄; silver(I) 4-methylbenzenesulfonate; In chloroform; at 55 ℃; for 72h; Concentration; Reagent/catalyst; Temperature; enantioselective reaction; Catalytic behavior; Inert atmosphere; Sealed tube;

DOI:10.1021/om300600v

Reference yield: 93.0%

2,2,2-trifluoro-N-(4-methoxy-phenyl)-acetimidic acid 5-methyl-hex-2-enyl ester → (S)-2,2,2-trifluoro-N-(4-methoxyphenyl)-N-(1-isobutylallyl)acetamide (562870-89-7)

Guidance literature:

With silver(I) 4-methylbenzenesulfonate; chiral ferrocenyl-bisimidazoline palladacycle; In chloroform; at 55 ℃; for 72h;

DOI:10.1002/anie.200603568

Reference yield:

(E)-5-methyl-2-hexenyl-N-(4-methoxyphenyl)trifluoroacetimidate → (S)-2,2,2-trifluoro-N-(4-methoxyphenyl)-N-(1-isobutylallyl)acetamide (562870-89-7) + (R)-2,2,2-trifluoro-N-(4-methoxyphenyl)-N-(1-isobutylallyl)acetamide (562870-90-0)

Guidance literature:

With chiral palladim(II)-based; In dichloromethane; at 23 ℃; for 60h; Title compound not separated from byproducts;

DOI:10.1021/ol0271786

upstream raw materials:

4-methoxy-aniline

(Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride

(E)-5-methylhex-2-en-1-ol

Downstream raw materials:

(S)-N-(4-methoxyphenyl)-3-amino-5-methyl-1-hexene