benzyl N-(2-morpholino-2-oxoethyl)carbamate

Base Information

• Chemical Name: benzyl N-(2-morpholino-2-oxoethyl)carbamate
• CAS No.: 56414-76-7
• Molecular Formula: C14H18N2O4
• Molecular Weight: 278.308
• DSSTox Substance ID: DTXSID90394849
• Wikidata: Q82194502
• ChEMBL ID: CHEMBL1525660
• Mol file: 56414-76-7.mol

Synonyms:56414-76-7;benzyl N-(2-morpholino-2-oxoethyl)carbamate;benzyl N-[2-(morpholin-4-yl)-2-oxoethyl]carbamate;benzyl N-(2-morpholin-4-yl-2-oxoethyl)carbamate;(2-Morpholin-4-yl-2-oxo-ethyl)-carbamic acid benzyl ester;MLS001166187;CHEMBL1525660;DTXSID90394849;HMS2884N12;AKOS005088823;SMR000550034;CS-0213458;3P-001;benzylN-[2-(morpholin-4-yl)-2-oxoethyl]carbamate

Chemical Property of benzyl N-(2-morpholino-2-oxoethyl)carbamate

Chemical Property:

• PSA: 71.36000
• LogP: 0.91390
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 278.12665706
• Heavy Atom Count: 20
• Complexity: 323

Purity/Quality:

99% ^*data from raw suppliers

(2-Morpholin-4-yl-2-oxo-ethyl)-carbamic acid benzyl ester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=O)CNC(=O)OCC2=CC=CC=C2

Technology Process of benzyl N-(2-morpholino-2-oxoethyl)carbamate

There total 5 articles about benzyl N-(2-morpholino-2-oxoethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

morpholine (110-91-8,99108-56-2) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → benzyl (2-morpholino-2-oxoethyl)carbamate (56414-76-7)

Guidance literature:

With dichloro(dimethylglyoxime)(dimethylglyoximato)cobalt(III); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine; In dichloromethane; at 20 ℃; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/anie.202112668

Reference yield: 80.0%

morpholine (110-91-8,99108-56-2) + Benzyloxycarbonylamino-acetic acid 1-methylene-pentyl ester (137862-14-7) → benzyl (2-morpholino-2-oxoethyl)carbamate (56414-76-7)

Guidance literature:

potassium cyanide; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4039(00)92385-2

Reference yield:

morpholine (110-91-8,99108-56-2) + arsenochloridous acid diethyl ester (4431-21-4) → benzyl (2-morpholino-2-oxoethyl)carbamate (56414-76-7)

Guidance literature:

With triethylamine; toluene; anschliessend Erhitzen mit N-Benzyloxycarbonyl-glycin;

DOI:10.1021/ja01147a548

upstream raw materials:

morpholine

arsenochloridous acid diethyl ester

Benzyloxycarbonylamino-acetic acid 1-methylene-pentyl ester

N-(Benzyloxycarbonyl)glycine