10.1016/j.ica.2007.06.041
The research investigates the synthesis, characterization, and antimicrobial properties of the first complexes formed between Zn(II), Cd(II), and Co(II) ions and N-benzyloxycarbonylglycine (N-Boc-glyH). The purpose of the study is to explore the coordination chemistry of these metal ions with N-Boc-glyH and to assess the potential antimicrobial activity of the resulting complexes. N-benzyloxycarbonylglycine (N-Boc-glyH) is the ligand used to form complexes with the metal ions. It serves as the coordinating molecule that binds to the metal centers in the Zn(II), Cd(II), and Co(II) complexes. Its presence is crucial for studying the coordination chemistry and antimicrobial properties of the resulting metal complexes. The metal salts were reacted with N-Boc-glyH in an ethanol-water mixture at pH 5–6 to form the complexes. The complexes were characterized using various techniques, including elemental analysis, IR spectroscopy, 1H and 13C NMR spectroscopy, and single-crystal X-ray diffraction for the Cd(II) complex. The study found that the complexes adopt different geometries: tetrahedral for Zn(II), distorted pentagonal-bipyramidal for Cd(II), and octahedral for Co(II). The Cd(II) complex forms a 2D supramolecular structure stabilized by non-covalent interactions. The antimicrobial assays revealed that the complexes, unlike the free ligand, inhibit the growth of Candida albicans, with the Cd(II) complex also showing activity against Aspergillus niger and certain bacteria. The study concludes that the coordination of N-Boc-glyH to metal ions enhances the antimicrobial activity, likely due to increased lipophilicity and permeation through microbial cell membranes.
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