2-(p-Methoxyphenyl)-4-(oxiranylmethoxy)-1-phenyl-1H-indole

Base Information

• Chemical Name: 2-(p-Methoxyphenyl)-4-(oxiranylmethoxy)-1-phenyl-1H-indole
• CAS No.: 76410-32-7
• Molecular Formula: C₂₄H₂₁NO₃
• Molecular Weight: 371.436
• Hs Code.: 2933990090
• Mol file: 76410-32-7.mol

Synonyms:

Chemical Property of 2-(p-Methoxyphenyl)-4-(oxiranylmethoxy)-1-phenyl-1H-indole

Chemical Property:

• Vapor Pressure: 5.58E-13mmHg at 25°C
• Boiling Point: 569.4°C at 760 mmHg
• Flash Point: 298.2°C
• PSA: 35.92000
• Density: 1.21g/cm³
• LogP: 5.08370

Purity/Quality:

2-(PARA-METHOXYPHENYL)-4-(OXIRANYLMETHOXY)-1-PHENYL-1H INDOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(p-Methoxyphenyl)-4-(oxiranylmethoxy)-1-phenyl-1H-indole

There total 4 articles about 2-(p-Methoxyphenyl)-4-(oxiranylmethoxy)-1-phenyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-p-Methoxyphenacylcyclohexane-1,3-dione (39992-64-8) → 2-(4-Methoxy-phenyl)-4-oxiranylmethoxy-1-phenyl-1H-indole (76410-32-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / acetic acid / 0.67 h / Heating

2: 81 percent / Raney nickel / toluene / 18 h / Heating

3: 1.) NaOH / 1.) dioxane, water, 2.) reflux

With sodium hydroxide; nickel; In acetic acid; toluene;

DOI:10.1007/BF00765625

Reference yield:

1-Phenyl-2-p-methoxyphenyl-4-oxo-4,5,6,7-tetrahydroindole (76410-25-8) → 2-(4-Methoxy-phenyl)-4-oxiranylmethoxy-1-phenyl-1H-indole (76410-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / Raney nickel / toluene / 18 h / Heating

2: 1.) NaOH / 1.) dioxane, water, 2.) reflux

With sodium hydroxide; nickel; In toluene;

DOI:10.1007/BF00765625

Reference yield:

2-Bromo-4'-methoxyacetophenone (2632-13-5) → 2-(4-Methoxy-phenyl)-4-oxiranylmethoxy-1-phenyl-1H-indole (76410-32-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 53 percent / aq. KOH / various solvent(s) / Ambient temperature

2: 63 percent / acetic acid / 0.67 h / Heating

3: 81 percent / Raney nickel / toluene / 18 h / Heating

4: 1.) NaOH / 1.) dioxane, water, 2.) reflux

With potassium hydroxide; sodium hydroxide; nickel; In acetic acid; toluene;

DOI:10.1007/BF00765625

upstream raw materials:

1-Phenyl-2-p-methoxyphenyl-4-hydroxyindole

epichlorohydrin

2-p-Methoxyphenacylcyclohexane-1,3-dione

1-Phenyl-2-p-methoxyphenyl-4-oxo-4,5,6,7-tetrahydroindole

Refernces