6-Methylimidazo[2,1-b][1,3]thiazole-5-carbaldehyde

Base Information

• Chemical Name: 6-Methylimidazo[2,1-b][1,3]thiazole-5-carbaldehyde
• CAS No.: 75001-31-9
• Molecular Formula: C7H6N2OS
• Molecular Weight: 166.203
• Hs Code.: 2934100090
• European Community (EC) Number: 878-112-1
• NSC Number: 315206
• DSSTox Substance ID: DTXSID90317391
• Wikidata: Q72491730
• Mol file: 75001-31-9.mol

Synonyms:75001-31-9;6-Methyl-imidazo[2,1-b]thiazole-5-carbaldehyde;6-Methylimidazo[2,1-b]thiazole-5-carbaldehyde;6-methylimidazo[2,1-b][1,3]thiazole-5-carbaldehyde;NSC 315206;6-Methylimidazo[2,1-b]thiazole-5-carboxaldehyde;NSC315206;B]THIAZOLE-5-;SCHEMBL6209906;DTXSID90317391;6-METHYL-IMIDAZO[2,1-;MFCD02253172;STK335038;AKOS000121656;NSC-315206;methylperfluoro(2-methyl-3-oxahexanoate);BP-11130;LS-06378;BB 0221315;FT-0671855;EN300-00977;A838305;J-518908;Z56792052;F2124-0674;6-methyl-imidazo[2,1-b]thiazole-5-carbaldehyde, AldrichCPR

Chemical Property of 6-Methylimidazo[2,1-b][1,3]thiazole-5-carbaldehyde

Chemical Property:

• Melting Point: 140-142 °C(Solv: ligroine (8032-32-4))
• Refractive Index: 1.719
• PKA: 4.96±0.40(Predicted)
• PSA: 62.61000
• Density: 1.45 g/cm³
• LogP: 1.51670
• Storage Temp.: 2-8°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 166.02008399
• Heavy Atom Count: 11
• Complexity: 176

Purity/Quality:

97% ^*data from raw suppliers

6-Methylimidazo[2,1-b]thiazole-5-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N2C=CSC2=N1)C=O
• Uses: 6-MethyliMidazo[2,1-b]thiazole-5-carboxaldehyde is used in the preparation of dihydropyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors for treating HIV infection.

Technology Process of 6-Methylimidazo[2,1-b][1,3]thiazole-5-carbaldehyde

There total 1 articles about 6-Methylimidazo[2,1-b][1,3]thiazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methylimidazo<2,1-b>thiazole (3835-41-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-methyl-imidazo[2,1-b]thiazole-5-carbaldehyde (75001-31-9)

Guidance literature:

With trichlorophosphate;

Reference yield: 69.0%

2-amino-benzenethiol (137-07-5) + malononitrile (109-77-3) + 6-methyl-imidazo[2,1-b]thiazole-5-carbaldehyde (75001-31-9) → 2-amino-6-[(2-aminophenyl)sulfanyl]-4-(6-methylimidazo[2,1-b][1,3]thiazol-5-yl)-1,4-dihydro-3,5-pyridinedicarbonitrile

Guidance literature:

With triethylamine; In ethanol; Heating;

DOI:10.1021/jo070114u

Reference yield: 68.0%

thiophenol (108-98-5) + malononitrile (109-77-3) + 6-methyl-imidazo[2,1-b]thiazole-5-carbaldehyde (75001-31-9) → 2-amino-4-(6-methylimidazo[2,1-b][1,3]thiazol-5-yl)-6-(phenylsulfanyl)-1,4-dihydro-3,5-pyridineducarbonitrile

Guidance literature:

With triethylamine; In ethanol; Heating;

DOI:10.1021/ol052994+ DOI:10.1021/jo070114u

upstream raw materials:

6-methylimidazo<2,1-b>thiazole

N,N-dimethyl-formamide

Downstream raw materials:

5-idrossimetil-6-metilimidazo<2,1-b>tiazolo

6-Methyl-imidazo[2,1-b]thiazole-5-carbaldehyde oxime

6-methylimidazo<2,1-b>thiazol-5-carboxamide

6-methylimidazo[2,1-b][1,3]thiazole-5-carbonitrile