Acetamide, N-[[(1R,3R,6S)-6-(1,1-dimethylethyl)-5-methoxy-6-methyl-8-oxo-7-oxa-4 -azaspiro[2.5]oct-4-en-1-yl]methyl]-2,2,2-trifluoro-N-[(phenylamino)carb onyl]-

Base Information

Chemical Name:Acetamide, N-[[(1R,3R,6S)-6-(1,1-dimethylethyl)-5-methoxy-6-methyl-8-oxo-7-oxa-4 -azaspiro[2.5]oct-4-en-1-yl]methyl]-2,2,2-trifluoro-N-[(phenylamino)carb onyl]-
CAS No.:565237-71-0
Molecular Formula:C22H26F3N3O5
Molecular Weight:469.461
Hs Code.:

Acetamide,
N-[[(1R,3R,6S)-6-(1,1-dimethylethyl)-5-methoxy-6-methyl-8-oxo-7-oxa-4
-azaspiro[2.5]oct-4-en-1-yl]methyl]-2,2,2-trifluoro-N-[(phenylamino)carb
onyl]-

Synonyms:

Suppliers and Price of Acetamide, N-[[(1R,3R,6S)-6-(1,1-dimethylethyl)-5-methoxy-6-methyl-8-oxo-7-oxa-4 -azaspiro[2.5]oct-4-en-1-yl]methyl]-2,2,2-trifluoro-N-[(phenylamino)carb onyl]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetamide, N-[[(1R,3R,6S)-6-(1,1-dimethylethyl)-5-methoxy-6-methyl-8-oxo-7-oxa-4 -azaspiro[2.5]oct-4-en-1-yl]methyl]-2,2,2-trifluoro-N-[(phenylamino)carb onyl]-

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Technology Process of Acetamide, N-[[(1R,3R,6S)-6-(1,1-dimethylethyl)-5-methoxy-6-methyl-8-oxo-7-oxa-4 -azaspiro[2.5]oct-4-en-1-yl]methyl]-2,2,2-trifluoro-N-[(phenylamino)carb onyl]-

There total 8 articles about Acetamide, N-[[(1R,3R,6S)-6-(1,1-dimethylethyl)-5-methoxy-6-methyl-8-oxo-7-oxa-4 -azaspiro[2.5]oct-4-en-1-yl]methyl]-2,2,2-trifluoro-N-[(phenylamino)carb onyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 58825-60-8
1-phenyl-3-(trifluoroacetyl)urea

: 565237-64-1
(1S,3R,6S)-6-tert-butyl-1-hydroxymethyl-5-methoxy-6-methyl-7-oxa-4-azaspiro[2.5]oct-4-en-8-one

: 565237-71-0
1-[(1R,3R,6S)-6-tert-butyl-5-methoxy-6-methyl-8-oxo-7oxa-4-azaspiro[2.5]oct-4-en-1-ylmethyl]-3-phenyl-1-(trifluoroacetyl)urea

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1002/ejoc.200390179

Reference yield:

: 918-10-5
(S)-(-)-2-hydroxy-2,3,3-trimethylbutanoic acid

: 565237-71-0
1-[(1R,3R,6S)-6-tert-butyl-5-methoxy-6-methyl-8-oxo-7oxa-4-azaspiro[2.5]oct-4-en-1-ylmethyl]-3-phenyl-1-(trifluoroacetyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / CDI / tetrahydrofuran / 20 h / 20 °C

2: 96 percent / H₂ / Pd/C / ethanol

3: 82 percent / 2-chloro-1-methylpyridinium iodide; ethyldiisopropylamine / CH₂Cl₂ / 4 h / Heating

4: 89 percent / CH₂Cl₂ / 24 h / 20 °C

5: 42 percent / NaN(SiMe₃)2 / tetrahydrofuran / 16 h / -20 °C

6: 65 percent / DIAD; PPh₃ / tetrahydrofuran / 24 h / 20 °C

With di-isopropyl azodicarboxylate; 2-chloro-1-methyl-pyridinium iodide; hydrogen; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 6: Mitsunobu reaction;
DOI:10.1002/ejoc.200390179

Reference yield:

: 565237-97-0
(S)-2-(N-benzyloxycarbonylaminoacetoxy)-2,3,3-trimethylbutanoic acid

: 565237-71-0
1-[(1R,3R,6S)-6-tert-butyl-5-methoxy-6-methyl-8-oxo-7oxa-4-azaspiro[2.5]oct-4-en-1-ylmethyl]-3-phenyl-1-(trifluoroacetyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / H₂ / Pd/C / ethanol

2: 82 percent / 2-chloro-1-methylpyridinium iodide; ethyldiisopropylamine / CH₂Cl₂ / 4 h / Heating

3: 89 percent / CH₂Cl₂ / 24 h / 20 °C

4: 42 percent / NaN(SiMe₃)2 / tetrahydrofuran / 16 h / -20 °C

5: 65 percent / DIAD; PPh₃ / tetrahydrofuran / 24 h / 20 °C

With di-isopropyl azodicarboxylate; 2-chloro-1-methyl-pyridinium iodide; hydrogen; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 5: Mitsunobu reaction;
DOI:10.1002/ejoc.200390179