Butanoic acid, 2-hydroxy-2,3,3-trimethyl-, (2S)-

Base Information

• Chemical Name: Butanoic acid, 2-hydroxy-2,3,3-trimethyl-, (2S)-
• CAS No.: 918-10-5
• Molecular Formula: C7H14O3
• Molecular Weight: 146.186

Synonyms:(-) 2,3,3-trimethyl-2-hydroxy-butanoic acid;(+)-2-tert-Butylmilchsaeure;(S)(+)-α-Hydroxy-α,β,β-trimethylbuttersaeure;

Chemical Property of Butanoic acid, 2-hydroxy-2,3,3-trimethyl-, (2S)-

Chemical Property:

• PSA: 57.53000
• LogP: 0.86810

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 2-hydroxy-2,3,3-trimethyl-, (2S)-

There total 2 articles about Butanoic acid, 2-hydroxy-2,3,3-trimethyl-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3,4,4-trimethyl-1-pentyn-3-ol (38484-41-2) → (S)-(-)-2-hydroxy-2,3,3-trimethylbutanoic acid (918-10-5)

Guidance literature:

Multistep reaction; (i) O₃, CHCl₃, (ii) H₂O₂, aq. KOH;

DOI:10.1039/jr9650002553

Reference yield:

(R,S)-2-hydroxy-2,3,3-trimethylbutanoic acid (4026-21-5) + L-Phenylalaninol (3182-95-4) → (S)-(-)-2-hydroxy-2,3,3-trimethylbutanoic acid (918-10-5) + (S)-2-Amino-3-phenyl-propan-1-ol; compound with (R)-2-hydroxy-2,3,3-trimethyl-butyric acid

Guidance literature:

In di-isopropyl ether; isopropyl alcohol; at 60 ℃; for 36h;

DOI:10.1002/ejoc.200390179

Reference yield: 86.0%

(S)-(-)-2-hydroxy-2,3,3-trimethylbutanoic acid (918-10-5) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → (S)-2-(N-benzyloxycarbonylaminoacetoxy)-2,3,3-trimethylbutanoic acid (565237-97-0)

Guidance literature:

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1002/ejoc.200390179

upstream raw materials:

(S)-3,4,4-trimethyl-1-pentyn-3-ol

(R,S)-2-hydroxy-2,3,3-trimethylbutanoic acid

L-Phenylalaninol

Downstream raw materials:

(S)-1,2-Propanediol

(S)-2-(N-benzyloxycarbonylaminoacetoxy)-2,3,3-trimethylbutanoic acid

(3R,6S)-3-benzyl-6-tert-butyl-5-methoxy-6-methyl-3,6-dihydro-2H-1,4-oxazin-2-one

(1R,3R,6S)-6-tert-butyl-5-methoxy-6-methyl-1-phenylaminomethyl-7-oxa-4-azaspiro[2.5]oct-4-en-8-one

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