10.1039/c8ob02582g
The research aims to develop a novel method for synthesizing 2-aryl indenones from 1,5-enyne substrates using a gold-catalyzed cycloisomerization/aerobic oxidation cascade strategy. The study explores the use of molecular oxygen as the oxidant to achieve this transformation in a single step. Key chemicals involved include 1,5-enyne substrates, Ph3PAuCl (tris(triphenylphosphine)gold(I) chloride), AgBF4 (silver tetrafluoroborate), and various other gold catalysts and ligands. The researchers optimized reaction conditions, such as solvent choice (toluene being the most effective) and catalyst combinations, to maximize the yield of indenones. They also conducted experiments to investigate the reaction mechanism, including heavy atom labeling and radical verification tests. The study concludes that indene is a key intermediate in the transformation process, and the oxidation likely involves radical intermediates. The method was successfully applied to the formal total synthesis of isoprekinamycin, demonstrating its utility in preparing biologically active compounds. The use of molecular oxygen as an environmentally friendly oxidant combined with gold catalysis provides a sustainable approach to synthesizing indenone scaffolds from simple precursors.
10.1515/znb-2002-1104
The research discusses the synthesis and reactivity of cyclopentadienyl and indenyl ligands bearing fluorinated pendant groups, with a focus on their potential as catalysts for olefin polymerization. The study investigates the stability of cationic complexes formed during catalyst activation and how modifying the ligand environment can influence the physicochemical properties of resulting polymers. The researchers synthesized a series of cyclopentadienes and indenes with fluorinated pendant groups and examined their reactivity towards various metallating agents. The crystal structure of one such complex, 1-trimethylsilyl-3-(diphenyl-ortho-fluorophenyl-methyl)-cyclopentadiene (3), was determined, revealing no interaction between the metal atoms and the fluorine atom due to the bulkiness of the ligand system.