Phenol,4-[[2-amino-4-[(4-methoxyphenyl)methyl]-1-methyl-1H-imidazol-5-yl]methyl]-

Base Information

• Chemical Name: Phenol,4-[[2-amino-4-[(4-methoxyphenyl)methyl]-1-methyl-1H-imidazol-5-yl]methyl]-
• CAS No.: 110189-03-2
• Molecular Formula: C19H21 N3 O2
• Molecular Weight: 323.395
• Mol file: 110189-03-2.mol

Synonyms:Naamine A

Chemical Property of Phenol,4-[[2-amino-4-[(4-methoxyphenyl)methyl]-1-methyl-1H-imidazol-5-yl]methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol,4-[[2-amino-4-[(4-methoxyphenyl)methyl]-1-methyl-1H-imidazol-5-yl]methyl]-

There total 41 articles about Phenol,4-[[2-amino-4-[(4-methoxyphenyl)methyl]-1-methyl-1H-imidazol-5-yl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-(4-(benzyloxy)benzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-amine (876945-81-2) → 4-((2-amino-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-5-yl)methyl)phenol (110189-03-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/ol052568o

Reference yield: 100.0%

C34H33N3O4 → 4-((2-amino-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-5-yl)methyl)phenol (110189-03-2)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol;

Reference yield: 84.0%

benzyl (Z)-4-(4-(benzyloxy)benzyl)-2-imino-5-(4-methoxybenzylidene)-3-methylimidazolidine-1-carboxylate → 4-((2-amino-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-5-yl)methyl)phenol (110189-03-2)

Guidance literature:

With palladium hydroxide, 20 wt% on carbon; hydrogen; In methanol; under 760.051 Torr; Inert atmosphere;

DOI:10.1021/acs.joc.5b01703

upstream raw materials:

naamidine A

2-amino-5-[1-(4-tert-butyldimethylsiloxyphenyl)methyl]-4-[1-(4-methoxyphenyl)methyl]-1-methyl-1H-imidazole

5-(4-(benzyloxy)benzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-amine

tert-butyl (3-(4-(benzyloxy)phenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Downstream raw materials:

naamidine A

Refernces

• 1、 Guo, Pengbin,Li, Gang,Liu, Yuxiu,Lu, Aidang,Wang, Ziwen,Wang, Qingmin. "Naamines and naamidines as novel agents against a plant virus and phytopathogenic fungi". . . Retrieved 2018/09/13.
• 2、 Gibbons, Joseph B.,Salvant, Justin M.,Vaden, Rachel M.,Kwon, Ki-Hyeok,Welm, Bryan E.,Looper, Ryan E.. "Synthesis of Naamidine A and Selective Access to N2-Acyl-2-aminoimidazole Analogues". . p. 10076 - 10085. Retrieved 2015/11/03.