naamidine A

Base Information

• Chemical Name: naamidine A
• CAS No.: 110189-06-5
• Molecular Formula: C23H23 N5 O4
• Molecular Weight: 433.467
• Mol file: 110189-06-5.mol

Synonyms:Naamidine A

Chemical Property of naamidine A

Chemical Property:

• Vapor Pressure: 1.26E-16mmHg at 25°C
• Boiling Point: 633.1°Cat760mmHg
• PKA: 9.96±0.15(Predicted)
• Flash Point: 336.7°C
• PSA: 112.54000
• Density: 1.35g/cm³
• LogP: 2.10540

Purity/Quality:

≥98% （HPLC） ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of naamidine A

There total 38 articles about naamidine A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-((2-amino-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-5-yl)methyl)phenol (110189-03-2) + 1-methyl-3-trimethylsilylparabanic acid (546113-06-8) → naamidine A (110189-06-5)

Guidance literature:

In toluene; for 18h; Reflux;

DOI:10.3390/md16090311

Reference yield: 76.0%

1-methylparabanic acid (3659-97-0) + 4-((2-amino-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-5-yl)methyl)phenol (110189-03-2) → naamidine A (110189-06-5)

Guidance literature:

1-methylparabanic acid; With N,O-Bis(trimethylsilyl)acetamide; In acetonitrile; for 2h; Reflux;

4-((2-amino-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-5-yl)methyl)phenol; In toluene; for 16h; Inert atmosphere; Reflux;

Reference yield:

5-(4-(benzyloxy)benzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-amine (876945-81-2) → naamidine A (110189-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / methanol

2: 57 mg / toluene / 18 h / Heating

With hydrogen; palladium on activated charcoal; In methanol; toluene;

DOI:10.1021/ol052568o

upstream raw materials:

1-methylparabanic acid

4-((2-amino-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-5-yl)methyl)phenol

1-methyl-3-trimethylsilylparabanic acid

tert-butyl (3-(4-(benzyloxy)phenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Downstream raw materials:

5-Hydroxy-4-[5-(4-hydroxy-benzyl)-4-(4-methoxy-benzyl)-1-methyl-1H-imidazol-2-ylamino]-1-methyl-imidazolidin-2-one

4-((2-amino-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-5-yl)methyl)phenol

Acetic acid 4-[5-(4-methoxy-benzyl)-3-methyl-2-(1-methyl-2,5-dioxo-2,5-dihydro-1H-imidazol-4-ylamino)-3H-imidazol-4-ylmethyl]-phenyl ester

Refernces

• 1、 -. "COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED 2-AMINOIMIDAZOLES". Paragraph 0019. . Retrieved 2018/10/25.
• 2、 -. "COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES". Paragraph 0190. . Retrieved 2015/11/10.