Technology Process of 11-Dodecen-3-one,
5-hydroxy-9-methoxy-10-(methoxymethoxy)-2,2-dimethyl-1-(phenylmeth
oxy)-7-[(triethylsilyl)oxy]-, (7S,9S,10S)-
There total 8 articles about 11-Dodecen-3-one,
5-hydroxy-9-methoxy-10-(methoxymethoxy)-2,2-dimethyl-1-(phenylmeth
oxy)-7-[(triethylsilyl)oxy]-, (7S,9S,10S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(benzyloxy)-3,3-dimethylbutan-2-one;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
(3R,5S,6S)-5-Methoxy-6-methoxymethoxy-3-triethylsilanyloxy-oct-7-enal;
In
tetrahydrofuran;
at -78 ℃;
DOI:10.1002/anie.200351145
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 97 percent / 2,6-lutidine / CH2Cl2
2.1: OsO4; NMO; H2O / acetone
2.2: 80 percent / Pb(OAc)4; pyridine / CH2Cl2
3.1: sBuLi; (+)-Ipc2BOMe / tetrahydrofuran / -78 - 0 °C
3.2: tetrahydrofuran / -95 - 20 °C
3.3: 91 percent / 30 percent H2O2; NaOH / tetrahydrofuran / 16 h
4.1: 89 percent / NaH / dimethylformamide / -5 °C
5.1: 88 percent / DDQ / CH2Cl2; H2O / 0 °C
6.1: 87 percent / py*SO3; Et3N / dimethylsulfoxide; CH2Cl2 / 0 °C
7.1: LDA / tetrahydrofuran / -78 °C
7.2: 94 percent / tetrahydrofuran / -78 °C
With
2,6-dimethylpyridine; osmium(VIII) oxide; N-methyl-2-indolinone; water; sec.-butyllithium; sulfur trioxide pyridine complex; sodium hydride; triethylamine; (+)-B-methoxydiisocamphenylborane; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1002/anie.200351145
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 97 percent / 2,6-lutidine / CH2Cl2
2.1: OsO4; NMO; H2O / acetone
2.2: 80 percent / Pb(OAc)4; pyridine / CH2Cl2
3.1: sBuLi; (+)-Ipc2BOMe / tetrahydrofuran / -78 - 0 °C
3.2: tetrahydrofuran / -95 - 20 °C
3.3: 91 percent / 30 percent H2O2; NaOH / tetrahydrofuran / 16 h
4.1: 89 percent / NaH / dimethylformamide / -5 °C
5.1: 88 percent / DDQ / CH2Cl2; H2O / 0 °C
6.1: 87 percent / py*SO3; Et3N / dimethylsulfoxide; CH2Cl2 / 0 °C
7.1: LDA / tetrahydrofuran / -78 °C
7.2: 94 percent / tetrahydrofuran / -78 °C
With
2,6-dimethylpyridine; osmium(VIII) oxide; N-methyl-2-indolinone; water; sec.-butyllithium; sulfur trioxide pyridine complex; sodium hydride; triethylamine; (+)-B-methoxydiisocamphenylborane; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1002/anie.200351145
