2-Bromo-1-indanone

Base Information

• Chemical Name: 2-Bromo-1-indanone
• CAS No.: 1775-27-5
• Molecular Formula: C9H7BrO
• Molecular Weight: 211.058
• Hs Code.: 29147000
• Mol file: 1775-27-5.mol

Synonyms:1-Indanone,2-bromo- (6CI,7CI,8CI);2-bromo-2,3-dihydro-1H-inden-1-one;2-Bromoindanone;1H-inden-1-one, 2-bromo-2,3-dihydro-;2-Brom-2,3-dihydro-1H-inden-1-on;2-Bromo-1-Indanone;2-Bromoindan-1-one;

Chemical Property of 2-Bromo-1-indanone

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.00308mmHg at 25°C
• Melting Point: 39-44 °C
• Refractive Index: 1.635
• Boiling Point: 283.9 °C at 760 mmHg
• Flash Point: 106.1 °C
• PSA: 17.07000
• Density: 1.631 g/cm³
• LogP: 2.18890

Purity/Quality:

99.0% ^*data from raw suppliers

2-Bromo-1-indanone 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 36/37/38-34
• Safety Statements: 24/25-36/37/39-27-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Bromo-1-indanone may be used in the preparation of trans-2-benzal-1-indanone epoxide via Darzens-type condensation with benzaldehyde. It may also be employed as substrate to investigate the substrate specificity of recombinant β-keto ester reductase (KER) of Penicillium citrinum.

Technology Process of 2-Bromo-1-indanone

There total 24 articles about 2-Bromo-1-indanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

inden-1-one (83-33-0) → 2-bromoindanone (1775-27-5)

Guidance literature:

Reference yield: 99.0%

1-Benzosuberone (826-73-3) → 2-bromoindanone (1775-27-5)

Guidance literature:

With bromine; In diethyl ether; Cooling with ice;

DOI:10.1016/j.tetlet.2009.10.042

Reference yield: 86.0%

1-indene (95-13-6) → 2-bromo-1-indanol (5400-80-6,78684-69-2) + 1,2-dibromoindane (20357-79-3) + 2-bromoindanone (1775-27-5)

Guidance literature:

With sodium bromate; sulfuric acid; sodium bromide; In 1,4-dioxane; water; at 20 ℃; for 6h;

DOI:10.1016/j.tetlet.2009.03.047

upstream raw materials:

2-bromo-1-indanol

trans-2-bromo-1-indanol

inden-1-one

3-azido-1H-indene

Downstream raw materials:

2-phenyl-8H-indeno[1,2-d]thiazole

3,8-dihydro-indeno[1,2-d]thiazol-2-one

2-(phenylthio)-2,3-dihydro-1H-inden-1-one

3,5-Dimethoxy-benzoic acid 1-oxo-indan-2-yl ester

Refernces

• 1、 Tandon, Vishnu K.,Awasthi, Anoop K.,Singh, Kunwar A.,Maurya, Hardesh K.,Gautam, Sanjay K.. "Nickel - promoted favorskii type rearrangement of cyclic α-bromoketones". . p. 593 - 600. Retrieved 2010.
• 2、 Prysiazhnuk, Dmitry V.,Rusanov, Eduard B.,Kolodiazhnyi, Oleg I.. "The absolute configuration of 2-bromo-2,3-dihydro-1H-inden-1-ols". supporting information. p. 3023 - 3031. Retrieved 2021/08/13.
• 3、 Quan, Bao-Xue,Yuan, Wei-Cheng,Zhang, Ming-Liang,Zhang, Xiao-Mei,Zhao, Jian-Qiang,Zhou, Ming-Qiang,Zhuo, Jun-Rui. "Annulation reaction of cyclic pyridinium ylides with: In situ generated azoalkenes for the construction of spirocyclic skeletons". supporting information. p. 1886 - 1891. Retrieved 2020/03/23.