3-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 3-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID
• CAS No.: 569687-82-7
• Molecular Formula: C₁₁H₁₄N₂O₄
• Molecular Weight: 238.243
• Hs Code.: 2933399090
• Mol file: 569687-82-7.mol

Synonyms:3-tert-butoxycarbonylaminopyridine-2-carboxylic acid;2-(2-Carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester;1-BOC-PIPERIDIN-2-YLPROPIONIC ACID;1-boc-piperidin-2-ylpropiomic acid;N-BOC-2-PIPERIDINEPROPANOIC ACID;N-Boc-2-piperidinepropionic acid;1-Boc-2-(2-Carboxyethyl)piperidine;3-[1-(tert-butoxycarbonyl)piperidin-2-yl]propionic acid;3-(N-Boc-amino)-pyridine-2-carboxylic acid;3-[1-(tert-butoxycarbonyl)piperidin-2-yl]propanoic acid;3-(N-Boc-2-piperidinyl)propanoic acid;

Chemical Property of 3-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID

Chemical Property:

• PSA: 92.01000
• LogP: 2.14040
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-(Boc-amino)pyridine-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID

There total 1 articles about 3-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-amino-pyridine-2-carboxylic acid (1462-86-8) → 3-tert-butoxycarbonylaminopyridine-2-carboxylic acid (569687-82-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 40 - 50 ℃;

DOI:10.1021/jm0300532

Reference yield:

3-tert-butoxycarbonylaminopyridine-2-carboxylic acid (569687-82-7) → 3-(3-fluoro-benzoylamino)-pyridine-2-carboxylic acid thiazol-2-ylamide

Guidance literature:

Multi-step reaction with 3 steps

1: 44 percent / HOBT; DCC / dimethylformamide / 24 h / 20 °C

2: 91 percent / TFA / CH₂Cl₂ / 4 h / -10 - 20 °C

3: 18 percent / aq. NaHCO₃ / ethyl acetate / 0 - 20 °C

With sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm0300532

Reference yield:

3-tert-butoxycarbonylaminopyridine-2-carboxylic acid (569687-82-7) → 3-(2-fluorobenzamido)-N-(thiazol-2-yl)picolinamide

Guidance literature:

Multi-step reaction with 3 steps

1: 44 percent / HOBT; DCC / dimethylformamide / 24 h / 20 °C

2: 91 percent / TFA / CH₂Cl₂ / 4 h / -10 - 20 °C

3: 19 percent / aq. NaHCO₃ / ethyl acetate / 0 - 20 °C

With sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm0300532

upstream raw materials:

di-tert-butyl dicarbonate

3-amino-pyridine-2-carboxylic acid

Downstream raw materials:

C₁₅H₁₃N₃O₂

2H-pyrido[3,2-d][1,3]oxazine-2,4-(1H)-dione