3-Aminopicolinic acid

Base Information

• Chemical Name: 3-Aminopicolinic acid
• CAS No.: 1462-86-8
• Molecular Formula: C6H6N2O2
• Molecular Weight: 138.126
• Hs Code.: 29333990
• European Community (EC) Number: 215-971-8
• UNII: KRX7SG6NCS
• DSSTox Substance ID: DTXSID00163301
• Nikkaji Number: J298.645K
• Wikidata: Q72441555
• ChEMBL ID: CHEMBL3617319
• Mol file: 1462-86-8.mol

Synonyms:3-aminopicolinic acid

Chemical Property of 3-Aminopicolinic acid

Chemical Property:

• Appearance/Colour: green/brown crystals
• Vapor Pressure: 1.14E-06mmHg at 25°C
• Melting Point: 218-220 °C
• Boiling Point: 386.6 °C at 760 mmHg
• PKA: 1.32±0.50(Predicted)
• Flash Point: 187.6 °C
• PSA: 76.21000
• Density: 1.417 g/cm³
• LogP: 0.94320
• Storage Temp.: -20°C Freezer
• Solubility.: Soluble in acetone, ethanol and methanol.
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 138.042927438
• Heavy Atom Count: 10
• Complexity: 138

Purity/Quality:

98% ^*data from raw suppliers

3-Aminopicolinic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37-60

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)C(=O)O)N
• Uses: 3-Amino-2-pyridinecarboxylic acid is a useful synthetic intermediate. Employed as an important intermediate for syntheses material and pharmaceutical.

Technology Process of 3-Aminopicolinic acid

There total 8 articles about 3-Aminopicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-nitropyridine-2-carboxylic acid (59290-85-6) → 3-amino-pyridine-2-carboxylic acid (1462-86-8)

Guidance literature:

3-nitropyridine-2-carboxylic acid; With hydrogen; sodium hydrogencarbonate; palladium 10% on activated carbon; In water; at 20 ℃; for 50h;

With hydrogenchloride; In water;

Reference yield: 10.0%

2,3-pyridinedicarboximide (4664-00-0,303983-78-0) → 3-amino-pyridine-2-carboxylic acid (1462-86-8)

Guidance literature:

With sodium hydroxide; sodium hypobromide; at 20 - 85 ℃; for 2h;

DOI:10.1016/S0968-0896(01)00115-8

Reference yield:

pyridine-2,3-dicarboxamide (4663-94-9) → 3-amino-pyridine-2-carboxylic acid (1462-86-8)

Guidance literature:

With sodium hydroxide; sodium hypobromide; acetic anhydride; Multistep reaction; 1.) 135 deg C, 2.) 80 deg C;

DOI:10.1021/jm9507993

upstream raw materials:

2,3-pyridinedicarboximide

pyridine-2,3-dicarboxamide

Pyridine-2,3-dicarboxylic acid

Pyridine-2,3-dicarboxylic anhydride

Downstream raw materials:

ethyl 3-aminopyridine-2-carboxylate

2-amino-3H-pyrido[3,2-d]pyrimidin-4-one

pyrido[3,2-d]-pyrimidin-4(3H)-one

3-phenylsulfanyl-pyridine-2-carboxylic acid

Refernces

• 1、 -. "Fused ring 4-oxopyrimidine derivative". Page/Page column 74. . Retrieved 2008/06/13.
• 2、 -. "AZA AND AZA (N-OXY) ANALOGS OF GLYCINE/NMDA RECEPTOR ANTAGONISTS". . . Retrieved 2008/06/13.