Technology Process of 1H-1-Benzazepine-5-acetic acid,
1-[[3-(4-aminophenyl)-5-isoxazolyl]methyl]-2,3,4,5-tetrahydro-2-oxo-,
1,1-dimethylethyl ester
There total 11 articles about 1H-1-Benzazepine-5-acetic acid,
1-[[3-(4-aminophenyl)-5-isoxazolyl]methyl]-2,3,4,5-tetrahydro-2-oxo-,
1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
at 20 ℃;
atmospheric pressure;
DOI:10.1016/S0968-0896(02)00616-8
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 87 percent / pyridine / tetrahydrofuran / 2 h / 20 °C
2.1: NaH / dimethylsulfoxide-d6; tetrahydrofuran / 20 °C
2.2: 57 percent / H2O / dimethylsulfoxide / 150 °C
3.1: NaH / dimethylformamide / 0 °C
3.2: 84.2 percent / dimethylformamide / 20 °C
4.1: H2 / 5 percent Pt/C / ethanol; dioxane / 96 h / 20 °C / atmospheric pressure
5.1: NaH / dimethylformamide / 1 h / 0 - 4 °C
5.2: 98 percent / KI / dimethylformamide / 0.5 h / 20 °C
6.1: 2.47 g / H2 / 10 percent Pd/C / ethanol / 20 °C / atmospheric pressure
With
pyridine; hydrogen; sodium hydride;
palladium on activated charcoal; platinum on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; dimethylsulfoxide-d6; ethanol; N,N-dimethyl-formamide;
2.1: Dieckmann condensation / 3.2: Wittig-Horner olefination;
DOI:10.1016/S0968-0896(02)00616-8
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaH / dimethylformamide / 1 h / 0 °C
1.2: 90.5 percent / dimethylformamide / 72 h / 20 °C
2.1: 96 percent / H2 / 10 percent Pd/C / ethanol; dioxane / 20 °C / atmospheric pressure
3.1: NaH / dimethylformamide / 1 h / 0 - 4 °C
3.2: 98 percent / KI / dimethylformamide / 0.5 h / 20 °C
4.1: 2.47 g / H2 / 10 percent Pd/C / ethanol / 20 °C / atmospheric pressure
With
hydrogen; sodium hydride;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; N,N-dimethyl-formamide;
1.2: Wittig-Horner olefination;
DOI:10.1016/S0968-0896(02)00616-8
![{1-[3-(4-nitro-phenyl)-isoxazol-5-ylmethyl]-2-oxo-2,3,4,5-tetrahydro-1<i>H</i>-benzo[<i>b</i>]azepin-5-yl}-acetic acid <i>tert</i>-butyl ester](/Databaselist/images/loading.webp)
