Technology Process of 1H-1-Benzazepine-5-acetic acid,
1-[[4-(4-aminophenyl)-2-thiazolyl]methyl]-2,3,4,5-tetrahydro-2-oxo-,
1,1-dimethylethyl ester
There total 13 articles about 1H-1-Benzazepine-5-acetic acid,
1-[[4-(4-aminophenyl)-2-thiazolyl]methyl]-2,3,4,5-tetrahydro-2-oxo-,
1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 87 percent / pyridine / tetrahydrofuran / 2 h / 20 °C
2.1: NaH / dimethylsulfoxide-d6; tetrahydrofuran / 20 °C
2.2: 57 percent / H2O / dimethylsulfoxide / 150 °C
3.1: NaH / dimethylformamide / 0 °C
3.2: 84.2 percent / dimethylformamide / 20 °C
4.1: H2 / 5 percent Pt/C / ethanol; dioxane / 96 h / 20 °C / atmospheric pressure
5.1: NaH / dimethylformamide / 1 h / 5 °C
5.2: 83 percent / dimethylformamide / 4 h / 20 °C
6.1: 5.5 g / H2S / pyridine / 20 °C
7.1: 98 percent / dioxane / 1 h / 20 °C
8.1: FeCl3; activated carbon; N2H4*H2O / methanol / 1 h
With
pyridine; hydrogen sulfide; hydrogen; iron(III) chloride; sodium hydride; pyrographite; hydrazine hydrate;
platinum on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dimethylsulfoxide-d6; ethanol; N,N-dimethyl-formamide;
2.1: Dieckmann condensation / 3.2: Wittig-Horner olefination;
DOI:10.1016/S0968-0896(02)00616-8
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: NaH / dimethylformamide / 1 h / 0 °C
1.2: 90.5 percent / dimethylformamide / 72 h / 20 °C
2.1: 96 percent / H2 / 10 percent Pd/C / ethanol; dioxane / 20 °C / atmospheric pressure
3.1: NaH / dimethylformamide / 1 h / 5 °C
3.2: 83 percent / dimethylformamide / 4 h / 20 °C
4.1: 5.5 g / H2S / pyridine / 20 °C
5.1: 98 percent / dioxane / 1 h / 20 °C
6.1: FeCl3; activated carbon; N2H4*H2O / methanol / 1 h
With
hydrogen sulfide; hydrogen; iron(III) chloride; sodium hydride; pyrographite; hydrazine hydrate;
palladium on activated charcoal;
In
1,4-dioxane; pyridine; methanol; ethanol; N,N-dimethyl-formamide;
1.2: Wittig-Horner olefination;
DOI:10.1016/S0968-0896(02)00616-8
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: H2O / dimethylsulfoxide / 150 °C
2.1: NaH / dimethylformamide / 1 h / 0 °C
2.2: 90.5 percent / dimethylformamide / 72 h / 20 °C
3.1: 96 percent / H2 / 10 percent Pd/C / ethanol; dioxane / 20 °C / atmospheric pressure
4.1: NaH / dimethylformamide / 1 h / 5 °C
4.2: 83 percent / dimethylformamide / 4 h / 20 °C
5.1: 5.5 g / H2S / pyridine / 20 °C
6.1: 98 percent / dioxane / 1 h / 20 °C
7.1: FeCl3; activated carbon; N2H4*H2O / methanol / 1 h
With
hydrogen sulfide; water; hydrogen; iron(III) chloride; sodium hydride; pyrographite; hydrazine hydrate;
palladium on activated charcoal;
In
1,4-dioxane; pyridine; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
2.2: Wittig-Horner olefination;
DOI:10.1016/S0968-0896(02)00616-8
