3-Oxazolidinecarboxylic acid, 4-[[3-[(3S)-7-bromo-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,3- dihydro-2-oxo-1-(phenylmethyl)-1H-indol-3-yl]-4-(phenylmethoxy)phenyl] methyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 4-[[3-[(3S)-7-bromo-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,3- dihydro-2-oxo-1-(phenylmethyl)-1H-indol-3-yl]-4-(phenylmethoxy)phenyl] methyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-
CAS No.:570377-15-0
Molecular Formula:C49H55BrN2O6Si
Molecular Weight:875.975
Hs Code.:

3-Oxazolidinecarboxylic acid,
4-[[3-[(3S)-7-bromo-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,3-
dihydro-2-oxo-1-(phenylmethyl)-1H-indol-3-yl]-4-(phenylmethoxy)phenyl]
methyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

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Suppliers and Price of 3-Oxazolidinecarboxylic acid, 4-[[3-[(3S)-7-bromo-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,3- dihydro-2-oxo-1-(phenylmethyl)-1H-indol-3-yl]-4-(phenylmethoxy)phenyl] methyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

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Chemical Property of 3-Oxazolidinecarboxylic acid, 4-[[3-[(3S)-7-bromo-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,3- dihydro-2-oxo-1-(phenylmethyl)-1H-indol-3-yl]-4-(phenylmethoxy)phenyl] methyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

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Technology Process of 3-Oxazolidinecarboxylic acid, 4-[[3-[(3S)-7-bromo-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,3- dihydro-2-oxo-1-(phenylmethyl)-1H-indol-3-yl]-4-(phenylmethoxy)phenyl] methyl]-2,2-dimethyl-, phenylmethyl ester, (4S)-

There total 13 articles about 3-Oxazolidinecarboxylic acid, 4-[[3-[(3S)-7-bromo-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,3- dihydro-2-oxo-1-(phenylmethyl)-1H-indol-3-yl]-4-(phenylmethoxy)phenyl] methyl]-2,2-dimethyl-, phenylmethyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 100-39-0
benzyl bromide

: 793724-16-0
4-{3-[7-bromo-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 570377-15-0
4-{3-[1-benzyl-7-bromo-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-benzyloxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: With potassium fluoride on basic alumina; In 1,2-dimethoxyethane; at 25 ℃; for 12h;
DOI:10.1021/ja040093a

Reference yield:

: 13512-31-7
N-(benzyloxycarbonyl)-L-tyrosine methyl ester

: 570377-15-0
4-{3-[1-benzyl-7-bromo-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-benzyloxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 21.8 g / TiCl₄ / CH₂Cl₂ / 6 h / 25 °C

2: SOCl₂ / 10 h / 25 °C

3: 15.7 g / NaCNBH₃ / acetonitrile / 5 h / 25 °C

4: 97 percent / LiBH₄ / tetrahydrofuran / 2 h / 25 °C

5: 98 percent / p-TsOH / acetone / 2 h / 25 °C

6: Et₃N / CH₂Cl₂ / 2 h / 0 °C

7: 7.38 g / aq. Yb(OTf)3 / tetrahydrofuran / 24 h / 25 °C

8: 84 percent / imidazole / CH₂Cl₂ / 6 h / 25 °C

9: 80 percent / LiOH / dimethylformamide / 5 h / 25 °C

10: 85 percent / KF*alumina / 1,2-dimethoxy-ethane / 12 h / 25 °C

With 1H-imidazole; lithium hydroxide; potassium fluoride on basic alumina; lithium borohydride; thionyl chloride; titanium tetrachloride; sodium cyanoborohydride; toluene-4-sulfonic acid; triethylamine; ytterbium(III) triflate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; 1: Fridel-Crafts reaction;
DOI:10.1021/ja040093a

Reference yield:

: 570377-13-8
{2-[3-(7-bromo-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid benzyl ester

: 570377-15-0
4-{3-[1-benzyl-7-bromo-3-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-benzyloxy-benzyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / p-TsOH / acetone / 2 h / 25 °C

2: Et₃N / CH₂Cl₂ / 2 h / 0 °C

3: 7.38 g / aq. Yb(OTf)3 / tetrahydrofuran / 24 h / 25 °C

4: 84 percent / imidazole / CH₂Cl₂ / 6 h / 25 °C

5: 80 percent / LiOH / dimethylformamide / 5 h / 25 °C

6: 85 percent / KF*alumina / 1,2-dimethoxy-ethane / 12 h / 25 °C

With 1H-imidazole; lithium hydroxide; potassium fluoride on basic alumina; toluene-4-sulfonic acid; triethylamine; ytterbium(III) triflate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja040093a