4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thi azolyl]amino]carbonyl]-2-pyridinyl]-, ethyl ester

Base Information

Chemical Name:4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thi azolyl]amino]carbonyl]-2-pyridinyl]-, ethyl ester
CAS No.:570403-14-4
Molecular Formula:C31H38Cl2N6O3S2
Molecular Weight:677.71
Hs Code.:

4-Piperidinecarboxylic acid,
1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thi
azolyl]amino]carbonyl]-2-pyridinyl]-, ethyl ester

Synonyms:

Suppliers and Price of 4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thi azolyl]amino]carbonyl]-2-pyridinyl]-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 11 raw suppliers

Chemical Property of 4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thi azolyl]amino]carbonyl]-2-pyridinyl]-, ethyl ester

Chemical Property:

Density:1.375±0.06 g/cm3(Predicted)

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

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Useful:

Technology Process of 4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thi azolyl]amino]carbonyl]-2-pyridinyl]-, ethyl ester

There total 6 articles about 4-Piperidinecarboxylic acid, 1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thi azolyl]amino]carbonyl]-2-pyridinyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 570407-42-0
4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolamine

: 931395-73-2
6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid

: 570403-14-4
ethyl 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylate

Guidance literature:: 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid; With thionyl chloride; N,N-dimethyl-aniline; In dichloromethane; at -20 ℃; for 1h;

4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolamine; In dichloromethane; at 20 ℃; for 1h; Temperature; Reagent/catalyst; Solvent;

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 570403-04-2
5,6-dichloro-N-[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]nicotinamide

: 570403-14-4
ethyl 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylate

Guidance literature:: In tetrahydrofuran; at 20 - 50 ℃; for 5h;

Reference yield:

: 570407-10-2
4-(4-chlorothiophen-2-yl)-1,3-thiazol-2-amine

: 570403-14-4
ethyl 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / 1-methyl-pyrrolidin-2-one / 0.5 h

1.2: 5 h / 60 °C

2.1: thionyl chloride; N,N-dimethyl-aniline / dichloromethane / 1 h / -20 °C

2.2: 1 h / 20 °C

With N-Bromosuccinimide; thionyl chloride; N,N-dimethyl-aniline; In 1-methyl-pyrrolidin-2-one; dichloromethane;