6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid

Base Information

• Chemical Name: 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid
• CAS No.: 931395-73-2
• Molecular Formula: C₁₄H₁₇ClN₂O₄
• Molecular Weight: 312.753
• Hs Code.: 2933399990

Synonyms:6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid

Chemical Property of 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid

Chemical Property:

• Melting Point: 128～130℃

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-6-[4-(ethoxycarbonyl)piperidino]-nicotinic acid >95% ^*data from reagent suppliers

Safty Information:

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Technology Process of 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid

There total 1 articles about 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-carbethoxypiperidine (1126-09-6) + 5,6-dichloronicotinic acid (41667-95-2) → 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid (931395-73-2)

Guidance literature:

In tetrahydrofuran; for 3h; Solvent; Reflux;

Reference yield: 83.0%

4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolamine (570407-42-0) + 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid (931395-73-2) → ethyl 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylate (570403-14-4)

Guidance literature:

6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid; With thionyl chloride; N,N-dimethyl-aniline; In dichloromethane; at -20 ℃; for 1h;

4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolamine; In dichloromethane; at 20 ℃; for 1h; Temperature; Reagent/catalyst; Solvent;

Reference yield:

4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolamine (570407-42-0) + 6-(4-(ethoxycarbonyl)piperidin-1-yl)-5-chloropyridine-3-carboxylic acid (931395-73-2) → 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid (570406-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride; N,N-dimethyl-aniline / dichloromethane / 1 h / -20 °C

1.2: 1 h / 20 °C

2.1: potassium hydroxide / isopropyl alcohol / 2 h / 60 °C

With thionyl chloride; N,N-dimethyl-aniline; potassium hydroxide; In dichloromethane; isopropyl alcohol;

upstream raw materials:

4-carbethoxypiperidine

5,6-dichloronicotinic acid

Downstream raw materials:

ethyl 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylate

1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid

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