tert-butyl 8,8-diMethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Base Information

• Chemical Name: tert-butyl 8,8-diMethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
• CAS No.: 570409-62-0
• Molecular Formula: C₁₅H₂₁N₃O₄
• Molecular Weight: 307.349
• Hs Code.: 2933990090
• Mol file: 570409-62-0.mol

Synonyms:t-butyl 8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate;tert-butyl 8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate;

Chemical Property of tert-butyl 8,8-diMethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Chemical Property:

• PSA: 88.25000
• LogP: 3.47920

Purity/Quality:

97% ^*data from raw suppliers

tert-butyl8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 8,8-diMethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

There total 3 articles about tert-butyl 8,8-diMethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-butan-2-one (563-80-4) → t-butyl 8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (570409-62-0)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. HCl / ethanol

2: H₂ / 10 percent Pd/C / ethanol

3: NH₃ / methanol

With hydrogenchloride; ammonia; hydrogen; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1016/S0960-894X(03)00288-9

Reference yield:

N-benzyl-3,3-dimethylpiperidine-4-one (173186-91-9) → t-butyl 8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (570409-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd/C / ethanol

2: NH₃ / methanol

With ammonia; hydrogen; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1016/S0960-894X(03)00288-9

Reference yield:

2-hydroxy-3,5-dinitropyridine (2980-33-8,222548-10-9) + tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate (324769-06-4) → t-butyl 8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (570409-62-0)

Guidance literature:

With ammonia; In methanol;

DOI:10.1016/S0960-894X(03)00288-9

upstream raw materials:

2-hydroxy-3,5-dinitropyridine

tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate

3-methyl-butan-2-one

N-benzyl-3,3-dimethylpiperidine-4-one

Downstream raw materials:

(E)-methyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)phenylcarbamate

(E)-tert-butyl 4-(3-amino-6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate

(E)-tert-butyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate

3-(4-ethoxy-3-trifluoromethyl-benzoylamino)-8,8-dimethyl-7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid tert-butyl ester