1-(TERT-BUTOXYCARBONYL)-3,3-DIMETHYL-4-OXOPIPERIDINE

Base Information

• Chemical Name: 1-(TERT-BUTOXYCARBONYL)-3,3-DIMETHYL-4-OXOPIPERIDINE
• CAS No.: 324769-06-4
• Molecular Formula: C12H21NO3
• Molecular Weight: 227.304
• Hs Code.: 2933399090
• Mol file: 324769-06-4.mol

Synonyms:1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine;1-tert-Butoxycarbonyl-3,3-dimethyl-4-piperidone;1-tert-Butyloxycarbonyl-3,3-dimethyl-4-piperidone;3,3-Dimethyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester;tert-Butyl3,3-dimethyl-4-oxopiperidine-1-carboxylate;

Chemical Property of 1-(TERT-BUTOXYCARBONYL)-3,3-DIMETHYL-4-OXOPIPERIDINE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.467
• Boiling Point: 303.418 °C at 760 mmHg
• PKA: -1.51±0.40(Predicted)
• Flash Point: 137.303 °C
• PSA: 46.61000
• Density: 1.035 g/cm³
• LogP: 2.16040
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl3,3-Dimethyl-4-oxopiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(TERT-BUTOXYCARBONYL)-3,3-DIMETHYL-4-OXOPIPERIDINE

There total 10 articles about 1-(TERT-BUTOXYCARBONYL)-3,3-DIMETHYL-4-OXOPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-benzyl-3,3-dimethylpiperidine-4-one (173186-91-9) → tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate (324769-06-4)

Guidance literature:

With sodium carbonate;

Reference yield: 88.5%

di-tert-butyl dicarbonate (24424-99-5) + N-benzyl-3,3-dimethylpiperidine-4-one (173186-91-9) → tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate (324769-06-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 16h; under 3345.86 Torr;

Reference yield: 76.0%

methyl iodide (74-88-4) → tert-butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate (324769-06-4)

Guidance literature:

N-tert-butyloxycarbonylpiperidin-4-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at 23 ℃; for 48h;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

methyl iodide

di-tert-butyl dicarbonate

N-benzyl-3,3-dimethylpiperidine-4-one

Downstream raw materials:

t-butyl 8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

tert-butyl 3-amino-8,8-dimethyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

3-(3-chloro-4-methoxy-benzoylamino)-8,8-dimethyl-7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid tert-butyl ester

3-(3-bromo-4-methoxy-benzoylamino)-8,8-dimethyl-7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES AS KINASE JAK INHIBITORS". Page/Page column 20; 21. . Retrieved 2018/12/02.
• 2、 -. "5- or 6-substituted benzofuran-2-carboxamide compounds and methods for using them". . . Retrieved 2016/09/12.