Technology Process of Cyclopropanecarboxylic acid, 1-methyl-2-phenyl-, methyl ester,
(1S,2S)-
There total 4 articles about Cyclopropanecarboxylic acid, 1-methyl-2-phenyl-, methyl ester,
(1S,2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
PdtBu3P)2; cesium fluoride;
In
benzene;
at 80 ℃;
for 1h;
DOI:10.1021/ja034210y
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: K2CO3 / methanol
1.2: t-BuOK / dimethylsulfoxide / 2 h / 50 °C
1.3: 52 percent / dimethylsulfoxide / 0.5 h
2.1: [Rh(COD)Cl]2; (R)-BINAP / tetrahydrofuran / 0.3 h / 20 °C
3.1: 100 percent / aq. HCl; NaIO4 / tetrahydrofuran / 1 h / 20 °C
4.1: 76 percent / PdtBu3P)2; CsF / benzene / 1 h / 80 °C
With
hydrogenchloride; sodium periodate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; PdtBu3P)2; potassium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; cesium fluoride;
In
tetrahydrofuran; methanol; benzene;
4.1: Suzuki cross-coupling reaction;
DOI:10.1021/ja034210y
- Guidance literature:
-
Multi-step reaction with 3 steps
1: [Rh(COD)Cl]2; (R)-BINAP / tetrahydrofuran / 0.3 h / 20 °C
2: 100 percent / aq. HCl; NaIO4 / tetrahydrofuran / 1 h / 20 °C
3: 76 percent / PdtBu3P)2; CsF / benzene / 1 h / 80 °C
With
hydrogenchloride; sodium periodate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; PdtBu3P)2; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; cesium fluoride;
In
tetrahydrofuran; benzene;
3: Suzuki cross-coupling reaction;
DOI:10.1021/ja034210y
