2H-1-Benzopyran-3-ol, 2-(dimethoxymethyl)-3,4-dihydro-4-[(1H-imidazol-2-ylmethyl)[4-(trifluoro methyl)phenyl]amino]-2-methyl-6-nitro-, (2R,3S,4R)-

Base Information

• Chemical Name: 2H-1-Benzopyran-3-ol, 2-(dimethoxymethyl)-3,4-dihydro-4-[(1H-imidazol-2-ylmethyl)[4-(trifluoro methyl)phenyl]amino]-2-methyl-6-nitro-, (2R,3S,4R)-
• CAS No.: 571141-42-9
• Molecular Formula: C₂₄H₂₅F₃N₄O₆
• Molecular Weight: 522.481

Synonyms:

Chemical Property of 2H-1-Benzopyran-3-ol, 2-(dimethoxymethyl)-3,4-dihydro-4-[(1H-imidazol-2-ylmethyl)[4-(trifluoro methyl)phenyl]amino]-2-methyl-6-nitro-, (2R,3S,4R)-

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Technology Process of 2H-1-Benzopyran-3-ol, 2-(dimethoxymethyl)-3,4-dihydro-4-[(1H-imidazol-2-ylmethyl)[4-(trifluoro methyl)phenyl]amino]-2-methyl-6-nitro-, (2R,3S,4R)-

There total 2 articles about 2H-1-Benzopyran-3-ol, 2-(dimethoxymethyl)-3,4-dihydro-4-[(1H-imidazol-2-ylmethyl)[4-(trifluoro methyl)phenyl]amino]-2-methyl-6-nitro-, (2R,3S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-trifluoromethylphenylamine (455-14-1) → (2R,3S,4R)-2-Dimethoxymethyl-4-[(1H-imidazol-2-ylmethyl)-(4-trifluoromethyl-phenyl)-amino]-2-methyl-6-nitro-chroman-3-ol (571141-42-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / methanol

2: CoCl₂ / acetonitrile

With sodium tetrahydroborate; In methanol; acetonitrile;

DOI:10.1016/S0960-894X(03)00248-8

Reference yield:

(2R)-6-nitro-2-methyl-2-dimethoxymethyl-3,4-epoxy-3,4-dihydro-2H-1-benzopyran (335382-11-1) + 4-trifluoromethylphenyl-1H-imidazol-2-ylmethylamine (660405-09-4) → (2R,3S,4R)-2-Dimethoxymethyl-4-[(1H-imidazol-2-ylmethyl)-(4-trifluoromethyl-phenyl)-amino]-2-methyl-6-nitro-chroman-3-ol (571141-42-9)

Guidance literature:

With CoCl₂; In acetonitrile;

DOI:10.1016/S0960-894X(03)00248-8

Reference yield:

(2R,3S,4R)-2-Dimethoxymethyl-4-[(1H-imidazol-2-ylmethyl)-(4-trifluoromethyl-phenyl)-amino]-2-methyl-6-nitro-chroman-3-ol (571141-42-9) → (2R,3S,4R)-6-Amino-2-dimethoxymethyl-4-[(1H-imidazol-2-ylmethyl)-(4-trifluoromethyl-phenyl)-amino]-2-methyl-chroman-3-ol

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/S0960-894X(03)00248-8

upstream raw materials:

(2R)-6-nitro-2-methyl-2-dimethoxymethyl-3,4-epoxy-3,4-dihydro-2H-1-benzopyran

4-trifluoromethylphenyl-1H-imidazol-2-ylmethylamine

4-trifluoromethylphenylamine

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