Slaframine

Base Information Edit

Chemical Name:Slaframine
CAS No.:20084-93-9
Molecular Formula:C₁₀H₁₈N₂O₂
Molecular Weight:198.265
Hs Code.:
UNII:51H2386GWI
DSSTox Substance ID:DTXSID50942108
Nikkaji Number:J15.531D
Wikipedia:Slaframine
Wikidata:Q1277175
Mol file:20084-93-9.mol

Synonyms:(1S,6S,8aS)-1-acetoxy-6-aminooctahydroindolizine;slaframine;slaframine citrate salt (1:2)

Suppliers and Price of Slaframine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(-)-Slaframine
10mg
$ 1540.00

Total 1 raw suppliers

Chemical Property of Slaframine Edit

Chemical Property:

Vapor Pressure:0.00425mmHg at 25°C
Boiling Point:278.5°Cat760mmHg
Flash Point:122.2°C
PSA：55.56000
Density:1.15g/cm³
LogP:0.75170
XLogP3:0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:198.136827821
Heavy Atom Count:14
Complexity:232

Purity/Quality:

97% ^*data from raw suppliers

(-)-Slaframine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)OC1CCN2C1CCC(C2)N
Isomeric SMILES:CC(=O)O[C@H]1CCN2[C@H]1CC[C@@H](C2)N
Description Certain legume forages used for dairy cattle feeding stock have been known to produce excessive salivation when infested by Rhizoctonia legurninicola and this has been shown to be due to the presence of an indolizidine alkaloid, slaframine. The base is amorphous and also yields an amorphous dihydrochloride. The dipicrate, however, is crystalline, m.p. l83-4°C as is also the N-acetyl derivative, m.p. l43-6°C; [α]25D - 15.9° (c 5.0, EtOH). NMR and high-resolution mass spectrometry have shown that the earlier structure required revision to that given above, namely l-acetoxy-6-aminooctahydroindolizidine. The configuration has been demonstrated to be 1 S,6S,8aS-.
Uses (-)-Slaframine, is an indolizidine alkaloidal mycotoxin that generally causes salivation (slobbers) in most animals. It is usually produced by the fungus Rhizoctonia leguminicola.

Technology Process of Slaframine

There total 114 articles about Slaframine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 153379-66-9
(1S,6S,8aS)-6-(benzyloxycarbonylamino)octahydroindolizin-1-yl acetate

: 20084-93-9,25357-19-1,30591-15-2,83602-26-0,114817-63-9,132486-20-5
(-)-slaframine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; acetic acid; at 20 ℃; for 1h;
DOI:10.1016/0040-4039(93)88117-2