Technology Process of Cyclopentanecarboxylic acid,
1-[[(3S,4R)-3-(3-fluorophenyl)-4-formyl-1-pyrrolidinyl]methyl]-,
phenylmethyl ester
There total 5 articles about Cyclopentanecarboxylic acid,
1-[[(3S,4R)-3-(3-fluorophenyl)-4-formyl-1-pyrrolidinyl]methyl]-,
phenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at -78 ℃;
DOI:10.1021/ol034707c
- Guidance literature:
-
Multi-step reaction with 5 steps
1: K2CO3 / dimethylsulfoxide
2: DIBAL / CH2Cl2 / -78 °C
3: NaB(OAc)3H / CH2Cl2
4: TBAF / tetrahydrofuran
5: (COCl)2; DMSO; (i-Pr)2NEt / CH2Cl2 / -78 °C
With
oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
5: Swern oxidation;
DOI:10.1021/ol034707c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: DIBAL / CH2Cl2 / -78 °C
2: NaB(OAc)3H / CH2Cl2
3: TBAF / tetrahydrofuran
4: (COCl)2; DMSO; (i-Pr)2NEt / CH2Cl2 / -78 °C
With
oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
4: Swern oxidation;
DOI:10.1021/ol034707c