Cyclopentanecarboxylic acid, 1-[[(3S,4S)-3-[[4-[1-ethyl-3-(phenylmethyl)-1H-pyrazol-5-yl]-1-piperidinyl] methyl]-4-(3-fluorophenyl)-1-pyrrolidinyl]methyl]-, phenylmethyl ester

Base Information

Chemical Name:Cyclopentanecarboxylic acid, 1-[[(3S,4S)-3-[[4-[1-ethyl-3-(phenylmethyl)-1H-pyrazol-5-yl]-1-piperidinyl] methyl]-4-(3-fluorophenyl)-1-pyrrolidinyl]methyl]-, phenylmethyl ester
CAS No.:573658-90-9
Molecular Formula:C42H51FN4O2
Molecular Weight:662.891
Hs Code.:

Cyclopentanecarboxylic acid,
1-[[(3S,4S)-3-[[4-[1-ethyl-3-(phenylmethyl)-1H-pyrazol-5-yl]-1-piperidinyl]
methyl]-4-(3-fluorophenyl)-1-pyrrolidinyl]methyl]-, phenylmethyl ester

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Chemical Property of Cyclopentanecarboxylic acid, 1-[[(3S,4S)-3-[[4-[1-ethyl-3-(phenylmethyl)-1H-pyrazol-5-yl]-1-piperidinyl] methyl]-4-(3-fluorophenyl)-1-pyrrolidinyl]methyl]-, phenylmethyl ester

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Technology Process of Cyclopentanecarboxylic acid, 1-[[(3S,4S)-3-[[4-[1-ethyl-3-(phenylmethyl)-1H-pyrazol-5-yl]-1-piperidinyl] methyl]-4-(3-fluorophenyl)-1-pyrrolidinyl]methyl]-, phenylmethyl ester

There total 6 articles about Cyclopentanecarboxylic acid, 1-[[(3S,4S)-3-[[4-[1-ethyl-3-(phenylmethyl)-1H-pyrazol-5-yl]-1-piperidinyl] methyl]-4-(3-fluorophenyl)-1-pyrrolidinyl]methyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15014-25-2
malonic acid dibenzyl ester

: 573658-90-9
1-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclopentanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / dimethylsulfoxide

2: DIBAL / CH₂Cl₂ / -78 °C

3: NaB(OAc)3H / CH₂Cl₂

4: TBAF / tetrahydrofuran

5: (COCl)2; DMSO; (i-Pr)2NEt / CH₂Cl₂ / -78 °C

6: NaB(OAc)3H / CH₂Cl₂

With oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 5: Swern oxidation;
DOI:10.1021/ol034707c

Reference yield:

: 208662-12-8
dibenzyl cyclopentane-1,1-dicarboxylate

: 573658-90-9
1-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclopentanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DIBAL / CH₂Cl₂ / -78 °C

2: NaB(OAc)3H / CH₂Cl₂

3: TBAF / tetrahydrofuran

4: (COCl)2; DMSO; (i-Pr)2NEt / CH₂Cl₂ / -78 °C

5: NaB(OAc)3H / CH₂Cl₂

With oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 4: Swern oxidation;
DOI:10.1021/ol034707c

Reference yield:

: 419571-32-7
benzyl 1-formylcyclopentanecarboxylate

: 573658-90-9
1-[(3S,4S)-3-[4-(5-Benzyl-2-ethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclopentanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaB(OAc)3H / CH₂Cl₂

2: TBAF / tetrahydrofuran

3: (COCl)2; DMSO; (i-Pr)2NEt / CH₂Cl₂ / -78 °C

4: NaB(OAc)3H / CH₂Cl₂

With oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 3: Swern oxidation;
DOI:10.1021/ol034707c