2-Butenoic acid, 4-[(2,2-diphenylethyl)amino]-4-oxo-, (2E)-

Base Information

• Chemical Name: 2-Butenoic acid, 4-[(2,2-diphenylethyl)amino]-4-oxo-, (2E)-
• CAS No.: 573986-12-6
• Molecular Formula: C18H17NO3
• Molecular Weight: 295.338
• Mol file: 573986-12-6.mol

Synonyms:

Chemical Property of 2-Butenoic acid, 4-[(2,2-diphenylethyl)amino]-4-oxo-, (2E)-

Chemical Property:

• PSA: 69.89000
• LogP: 3.41580

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Butenoic acid, 4-[(2,2-diphenylethyl)amino]-4-oxo-, (2E)-

There total 2 articles about 2-Butenoic acid, 4-[(2,2-diphenylethyl)amino]-4-oxo-, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

fumaric acid mono-2,2-diphenylethylamide monoethyl ester (573986-11-5) → (E)-4-((2,2-diphenylethyl)amino)-4-oxobut-2-enoic acid (573986-12-6)

Guidance literature:

With sodium hydroxide; In ethanol; water;

DOI:10.1002/anie.200250745

Reference yield:

2,2-Diphenylethylamine (3963-62-0) → (E)-4-((2,2-diphenylethyl)amino)-4-oxobut-2-enoic acid (573986-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / 4-DMAP; 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride / CH₂Cl₂ / 24 h

2: 91 percent / aq. NaOH / ethanol / 16 h

With dmap; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;

DOI:10.1021/ja036665t

Reference yield: 90.0%

tert-butyl (12-aminododecyl)carbamate (109792-60-1) + (E)-4-((2,2-diphenylethyl)amino)-4-oxobut-2-enoic acid (573986-12-6) → (E)-N-(12-Boc-aminododecyl)-4-(2,2-diphenylethylamine)-4-oxobut-2-enamide

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; for 4h; Inert atmosphere;

DOI:10.1039/c5cc04365d

upstream raw materials:

fumaric acid mono-2,2-diphenylethylamide monoethyl ester

2,2-Diphenylethylamine

Downstream raw materials:

N-{12-[3-(2,2-diphenyl-ethylcarbamoyl)-acryloylamino]-dodecyl}-succinamic acid 2,2-diphenyl-ethyl ester

(2S)-(2-{11-[3-(2,2-diphenyl-ethylcarbamoyl)-(E)-acryloylamino]-undecanoylamino}-acetylamino)-4-methyl-pentanoic acid 2,2-diphenyl-ethyl ester

{2-[(Anthracene-9-carbonyl)-amino]-acetylamino}-acetic acid 11-[(E)-3-(2,2-diphenyl-ethylcarbamoyl)-acryloylamino]-undecyl ester

{11-[3-(2,2-diphenyl-ethylcarbamoyl)-acryloylamino]-6-hydroxymethyl-undecyl}-carbamic acid 9H-fluoren-9-ylmethyl ester