Chemical Property of Oxysophoridine
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:208℃
- Refractive Index:1.637
- Boiling Point:957.115°C at 760 mmHg
- PKA:4.87±0.20(Predicted)
- Flash Point:532.644°C
- PSA：49.74000
- Density:1.399g/cm3
- LogP:1.78100
- Storage Temp.:2-8°C
- Solubility.:methanol: soluble10mg/mL, clear, colorless
- XLogP3:1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:0
- Exact Mass:264.183778013
- Heavy Atom Count:19
- Complexity:400
- Purity/Quality:
-
99% *data from raw suppliers
Oxymatrine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-20/22
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-]
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Description
An alkaloid from Sophora angustifolia var. flavescens S. and Z., the bas'e crystal_x0002_lizes as the monohydrate having the lower melting point given above. It is
dextrorotatory with [α]19D + 47.7° (EtOH) and yields crystalline salts and
derivatives: hydrobromide, m.p. 21SoC; aurichloride, m.p. 207°C (dec.); perchlorate, m.p. 240°C (dec.); picrate, m.p. 21SoC and the methochloride aurichloride, m.p. 18SoC (dec.). Ochiai and Ito have shown that it is formed by the
action of hydrogen peroxide on Matrine (q.v.), indicating that its structure is
matrine-N-oxide. Oxymatrine is a natural alkaloid isolated from the root of S. flavescens, an herb used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B alone and in combination with lamivudine. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-β signaling. Ammothamnine also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of nuclear factors-κB.
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Uses
Oxymatrine is a an anti-tumor agent triggering apoptosis in human leukemia cells. antifungal, hepatoprotectant
